Evidence map›Paper›PMID 36651955›Full record

ArticleEuropean radiology2023

Using T1 mapping indices to evaluate muscle function and predict conservative treatment outcomes in diabetic patients with peripheral arterial disease.

Yu-Ching Lin, Tieh-Cheng Fu, Gigin Lin, Shu-Hang Ng, Chi-Hsiao Yeh, Soh-Chin Ng, Tsun-Ching Chang, Yu-Hsiang Juan

Registry-linked trialAbstract read
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In one paragraph

Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02850432 (The Evolution and Impact of Clinical and MRI Cardiac Biomarkers on Peripheral Arterial Disease in Patients With Long Term DM), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02850432 naunknown statusnot on this map

The Evolution and Impact of Clinical and MRI Cardiac Biomarkers on Peripheral Arterial Disease in Patients With Long Term DM

TypeinterventionalSponsorChang Gung Memorial HospitalRan2016 to 2019Enrolled60ConditionsPeripheral Arterial DiseaseArmsInvasive treatment, Conservative treatment
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Abdominal TMagma (New York, N.Y.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu-Ching LinDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Keelung, Institute for Radiological Research, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Tieh-Cheng FuDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Keelung, Chang Gung University, Taoyuan, Taiwan.
Gigin LinDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan.
Shu-Hang NgDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan.
Chi-Hsiao YehDepartment of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital at Keelung and Linkou, Chang Gung University, Taoyuan, Taiwan.
Soh-Chin NgDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Keelung, Chang Gung University, Taoyuan, Taiwan.
Tsun-Ching ChangDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Keelung, Institute for Radiological Research, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Yu-Hsiang JuanDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan. jonat126@yahoo.com.tw.

Funding

Chang Gung Medical Foundation CMRPG3C1861-3Chang Gung Medical Foundation CMRPG3F1311-3Ministry of Science and Technology, Taiwan MOST 108-2314-B-182A-018-MY3Ministry of Science and Technology, Taiwan MOST 109-2314-B-182A-048
6 · The paper itself

Abstract

objectivesTo investigate interstitial muscle fibrosis via T1 mapping indices and its relationships with muscle function and conservative treatment outcomes.

methodsA total of 49 DM patients with PAD were prospectively recruited from 2016 to 2017. All PAD patients underwent pre-treatment MRI with conservative treatment via a rehabilitation program and antiplatelet therapy. The need to require percutaneous transluminal angioplasty intervention was recorded as intolerance to conservative treatment outcomes. We quantified calf interstitial muscle fibrosis using T1 mapping indices (native T1, post-contrast T1, and the extracellular volume fraction [ECV]). Muscle function was evaluated using a 6-min walking test (6MWT) and a 3-min stepping test (3MST). PAD patients were divided into two groups according to their tolerance or intolerance of the conservative treatment. Pearson's correlation, reproducibility, and multivariable Cox hazard analyses were performed with p < 0.05 indicating statistical significance.

resultsAmong the T1 mapping indices in the posterior compartment of the calf in PAD patients, the native T1 value was significantly correlated with 6MWT (r =  -0.422, p = 0.010) and 3MST (r =  -0.427, p = 0.009). All T1 mapping indices showed excellent intra-observer and inter-observer correlations. ECV was an independent predictor of conservative treatment intolerance (average ECV, hazard ratio: 1.045, 95% confidence interval: 1.011-1.079, p = 0.009).

conclusionsT1 mapping measurements are reproducible with excellent intra-observer and inter-observer correlations. T1 mapping indices may be predictive of treatment and functional outcomes and carry promise in patient evaluation.

trial registrationClinical Trials Identifier: NCT02850432 . KEY POINTS: • T1 mapping measurements of the calf muscles are reproducible with excellent intra-observer and inter-observer correlations (0.98 and 0.95 for anterior and posterior compartment muscle extracellular volume matrix [ECV] measurements, respectively). • ECV is shown to independently predict conservative treatment intolerance. • T1 mapping indices may be predictive of treatment and functional outcomes and carry promise in patient evaluation.

Indexed as

Diabetes MellitusPeripheral Arterial DiseaseConservative TreatmentContrast MediaFibrosisHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMyocardiumPredictive Value of TestsReproducibility of ResultsContrast MediaConservative treatmentDiabetes mellitusFibrosisPercutaneous transluminal angioplastyPeripheral arterial disease

Identifiers

PMID36651955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.