SynthesisEuropean journal of nuclear medicine and molecular imaging2023
Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies.
Synthesis in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- PET pharmacokinetics of [¹⁸F]F-AraG as a marker of T cell activation during immunotherapy with a STING agonist with and without anti-PD-1.EJNMMI research · 2026Article
- Biodistribution, Radiation Dosimetry, and Kinetic Modeling of [Pharmaceuticals (Basel, Switzerland) · 2026Article
- First Experience with [Diagnostics (Basel, Switzerland) · 2026Article
- A robust and versatile deep learning model for prediction of the arterial input function in dynamic small animal [EJNMMI research · 2026Article
- Patlak-PBNT: a simple population-based Patlak model to generate [EJNMMI physics · 2026Article
- External validation and time-stability analysis of STARE, a blood-free quantification tool for irreversible PET tracers.bioRxiv : the preprint server for biology · 2026Article
- Molecular Imaging of Pancreatic Duct Adenocarcinoma Using [Molecular imaging and biology · 2026Article
- Quantification of [Frontiers in neuroscience · 2026Article
- [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Kinetic modeling ofEJNMMI research · 2025Article
- Validating the Utility of Supervised Clustering Algorithm for Precise [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Quantitative PET imaging and modeling of molecular blood-brain barrier permeability.Nature communications · 2025Article
- A non-invasive, reference region-based method for quantification of cerebral blood flow and oxygen metabolism using oxygen-15 labeled gases and positron emission tomography.Asia Oceania journal of nuclear medicine & biology · 2025Article
- Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic SV2A density in healthy rat brain: An in vivo microPET study.Psychophysiology · 2025Article
- Evaluating image-derived input functions for cerebral [Frontiers in nuclear medicine · 2025Article
- Future prospects for image-derived input function in molecular imaging quantification with the 7 T MR-BrainPET insert.Frontiers in neuroscience · 2025Article
- Exact parameter identification in PET pharmacokinetic modeling using the irreversible two tissue compartment modelPhysics in medicine and biology · 2024Article
- Optimization-derived blood input function using a kernel method and its evaluation with total-body PET for brain parametric imaging.NeuroImage · 2024Article
- Beyond stillness: the importance of tackling patient's motion for reliable parametric imaging.European journal of nuclear medicine and molecular imaging · 2024Article
- Kinetic analysis of cardiac dynamicHeliyon · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Pharmacokinetic modelling with arterial sampling is the gold standard for analysing dynamic PET data of the brain. However, the invasive character of arterial sampling prevents its widespread clinical application. Several methods have been developed to avoid arterial sampling, in particular reference region methods. Unfortunately, for some tracers or diseases, no suitable reference region can be defined. For these cases, other potentially non-invasive approaches have been proposed: (1) a population based input function (PBIF), (2) an image derived input function (IDIF), or (3) simultaneous estimation of the input function (SIME). This systematic review aims to assess the correspondence of these non-invasive methods with the gold standard. Studies comparing non-invasive pharmacokinetic modelling methods with the current gold standard methods using an input function derived from arterial blood samples were retrieved from PubMed/MEDLINE (until December 2021). Correlation measurements were extracted from the studies. The search yielded 30 studies that correlated outcome parameters (V
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