Evidence map›Paper›PMID 36651940›Full record

ArticleDiabetologia2023

Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia.

Matthew J L Hare, Louise J Maple-Brown, Jonathan E Shaw, Jacqueline A Boyle, Paul D Lawton, Elizabeth L M Barr, Steven Guthridge, Vanya Webster, Denella Hampton, Gurmeet Singh and 2 more

Open access · hybridFull text read
In one paragraph

Article in Diabetologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Kidney Dysfunction Following Gestational Diabetes Mellitus.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Matthew J L HareMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia. matthew.hare@menzies.edu.au.ORCID http://orcid.org/0000-0002-9364-3368
Louise J Maple-BrownMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.ORCID https://orcid.org/0000-0002-9067-2737
Jonathan E ShawClinical Diabetes and Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-6187-2203
Jacqueline A BoyleEastern Health Clinical School, Monash University, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-3616-1637
Paul D LawtonMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.ORCID https://orcid.org/0000-0002-5754-4821
Elizabeth L M BarrMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.ORCID https://orcid.org/0000-0003-4284-1716
Steven GuthridgeMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.ORCID https://orcid.org/0000-0003-1495-764X
Vanya WebsterAboriginal and Torres Strait Islander Advisory Group, Diabetes across the Lifecourse: Northern Australia Partnership, Menzies School of Health Research, Darwin, NT, Australia.
Denella HamptonAboriginal and Torres Strait Islander Advisory Group, Diabetes across the Lifecourse: Northern Australia Partnership, Menzies School of Health Research, Darwin, NT, Australia.
Gurmeet SinghMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.ORCID https://orcid.org/0000-0002-7352-1339
Roland F DyckDepartment of Medicine and Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, SK, Canada.
Federica BarziMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.ORCID https://orcid.org/0000-0001-7427-0167
Charles Darwin University · AUBaker Heart and Diabetes Institute · AUCentral Land Council · AUEastern Health · AUMenzies School of Health Research · AUThe University of Queensland · AUUniversity of Saskatchewan · CA

Funding

National Health and Medical Research Council 1194698
6 · The paper itself

Abstract

aims/hypothesisThe aim of this work was to investigate the risk of developing chronic kidney disease (CKD) or end-stage kidney disease (ESKD) following a pregnancy complicated by gestational diabetes mellitus (GDM) or pre-existing diabetes among Aboriginal women in the Northern Territory (NT), Australia.

methodsWe undertook a longitudinal study of linked healthcare datasets. All Aboriginal women who gave birth between 2000 and 2016 were eligible for inclusion. Diabetes status in the index pregnancy was as recorded in the NT Perinatal Data Collection. Outcomes included any stage of CKD and ESKD as defined by ICD-10 coding in the NT Hospital Inpatient Activity dataset between 2000 and 2018. Risk was compared using Cox proportional hazards regression.

resultsAmong 10,508 Aboriginal women, the mean age was 23.1 (SD 6.1) years; 731 (7.0%) had GDM and 239 (2.3%) had pre-existing diabetes in pregnancy. Median follow-up was 12.1 years. Compared with women with no diabetes during pregnancy, women with GDM had increased risk of CKD (9.2% vs 2.2%, adjusted HR 5.2 [95% CI 3.9, 7.1]) and ESKD (2.4% vs 0.4%, adjusted HR 10.8 [95% CI 5.6, 20.8]). Among women with pre-existing diabetes in pregnancy, 29.1% developed CKD (adjusted HR 10.9 [95% CI 7.7, 15.4]) and 9.9% developed ESKD (adjusted HR 28.0 [95% CI 13.4, 58.6]). CONCLUSIONS/

interpretationAboriginal women in the NT with GDM or pre-existing diabetes during pregnancy are at high risk of developing CKD and ESKD. Pregnancy presents an important opportunity to identify kidney disease risk. Strategies to prevent kidney disease and address the social determinants of health are needed.

Indexed as

Diabetes, GestationalKidney Failure, ChronicRenal Insufficiency, ChronicAdultFemaleHumansLongitudinal StudiesNorthern TerritoryPregnancyYoung AdultAboriginal AustraliansChronic kidney diseaseDiabetes, gestationalEnd-stage kidney diseaseIndigenous peoplesOceanic Ancestry GroupPregnancy complicationsPregnancy in diabetesType 2 diabetes

Identifiers

PMID36651940
PMCPMC10036460
OpenAlexW4317209197

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read43
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.