Evidence map›Paper›PMID 36651918›Full record

ArticleNMR in biomedicine2023

More than one-half of the variance in in vivo proton MR spectroscopy metabolite estimates is common to all metabolites.

James J Prisciandaro, Helge J Zöllner, Saipavitra Murali-Manohar, Georg Oeltzschner, Richard A E Edden

Abstract read
In one paragraph

Article in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James J PrisciandaroDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7148-292X
Saipavitra Murali-ManoharRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3083-9811
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Lisa M McTeague · 1996 to 2026
$46.8M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Richard Anthony Edward Edden · 2021 to 2026
$9.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Gabapentin for Restoring GABA/glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Clinical MRI StudyR01DA054275 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2021 to 2025
$3.1M
Imaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar AlcoholicsR01AA025365 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2017 to 2022
$2.7M
Mentorship and Research in Bipolar and Substance Use DisordersK24AA030788 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI James Joseph Prisciandaro · 2023 to 2026
$860k
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
NIAAA NIH HHS K24 AA030788NIAAA NIH HHS P50 AA010761NIAAA NIH HHS R01 AA025365NIA NIH HHS R00 AG062230NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIBIB NIH HHS R21 EB033516NIDA NIH HHS R01 DA054275
6 · The paper itself

Abstract

The present study characterized associations among brain metabolite levels, applying bivariate and multivariate (i.e., factor analysis) statistical methods to total creatine (tCr)-referenced estimates of the major Point RESolved Spectroscopy (PRESS) proton MR spectroscopy (

Indexed as

Cytomegalovirus InfectionsProtonsAspartic AcidBrainCholineCreatineFemaleHumansInositolMagnetic Resonance SpectroscopyProton Magnetic Resonance SpectroscopyReceptors, Antigen, T-CellWaterAspartic AcidCholineCreatineInositolProtonsReceptors, Antigen, T-CellWater1H-MRSagecommon metabolite variancecovariancefactor analysisproton magnetic resonance spectroscopysexunique metabolite variance

Identifiers

PMID36651918
PMCPMC10272046

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.