ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023
The impact of acute kidney injury with or without recovery on long-term kidney outcome in patients undergoing living liver transplantation.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Risk Factors and Outcomes Associated With the Development of Persistent Acute Kidney Injury in Non-Renal Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis.Clinical transplantation · 2024Pooled it
- Frequency of acute kidney injury in post-liver transplantation and associated factors: a systematic review.Jornal brasileiro de nefrologiaPooled it
- Machine learning-based nomogram for acute kidney injury after liver transplantation.Renal failure · 2026Article
- Intraoperative renal oxygen saturation trajectories are associated with early postoperative acute kidney injury after liver transplantation.Scientific reports · 2026Article
- Advances in the postoperative care of the liver transplant recipient.Current opinion in critical care · 2026Review
- Impact of Early Allograft Dysfunction on Renal Function Outcomes Following Liver Transplantation.Medicina (Kaunas, Lithuania) · 2026Article
- Intraoperative allogeneic blood transfusion is not associated with postoperative acute kidney injury and in-hospital mortality in liver transplantation patients: a propensity score matching analysis.Frontiers in medicine · 2026Article
- Metabolic syndrome after liver transplantation: A silent threat to long-term success.World journal of gastrointestinal pharmacology and therapeutics · 2025Review
- Incidence and Risk Factors for Progression of Acute Kidney Injury to Chronic Kidney Disease After Liver Transplantation: A Retrospective Cohort Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Protective value of ischemia-free liver transplantation on post-transplant acute kidney injury.JHEP reports : innovation in hepatology · 2025Article
- Optimizing kidney health following pediatric liver transplantation: current challenges and future directions.Pediatric nephrology (Berlin, Germany) · 2025Article
- Outcomes of patients with infective endocarditis-associated acute kidney injury: a retrospective cohort study.Clinical kidney journal · 2025Article
- Clinical characteristics and outcomes of patients on haemodialysis at Jimma medical center, Ethiopia: a 7-Year review.BMC nephrology · 2024Article
- Risk Evaluation and Recipient Selection in Adult Liver Transplantation: A Mixed-Methods Survey.Canadian liver journal · 2024Article
- Development of a nomogram for the prediction of acute kidney injury after liver transplantation: a model based on clinical parameters and postoperative cystatin C level.Annals of medicine · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is associated with an increased incidence of poor liver graft and renal outcomes in patients who have undergone liver transplantation (LT). To date, no comprehensive study has compared patients with and without post-LT AKI and analyzed patients who recovered from AKI versus those who did not.
methodsPatients who received living LT between January 2003 and January 2019 were enrolled. We diagnosed and classified AKI patients based on AKI-KDIGO guidelines by increment of creatinine after surgery when compared with serum creatinine on the day of surgery. The recovered AKI subgroup included recipients whose estimated glomerular filtration rate (eGFR) recovered more than 90% of baseline eGFR within 90 days after surgery. The risk of chronic kidney disease (CKD; eGFR <60 mL/min/1.73 m2) was investigated.
resultsA total of 392 patients, 77.3% men and mean ± standard deviation age 54.1 ± 8.4 years, met the eligible criteria and were divided into two groups (AKI vs non-AKI) and 243 (62%) patients developed AKI within 7 days after surgery. Compared with the non-AKI group, the AKI group was associated with an adjusted hazard ratio of 1.55 (95% CI 1.12-2.14) for the risk of incident CKD. Among AKI patients, 160 (65.8%) patients recovered renal function and 83 (34.2%) patients did not. Compared with the non-AKI group, the AKI non-recovery group was associated with an adjusted hazard ratio of 2.87 (95% CI 1.95-4.21) for the risk of incident CKD, while the AKI recovery group had no significant difference in the adjusted risk of incident CKD.
conclusionsPost-LT AKI is associated with subsequent risk of CKD development. Taking into account recovery status, AKI was no longer associated with a higher risk of CKD if renal function recovered within 90 days after surgery. Identification and implementation of targeted and individualized therapies for patients at risk for AKI, particularly non-recovery AKI, is of paramount importance to reduce incident CKD during follow-up.
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