Evidence map›Paper›PMID 36651770›Full record

ArticleMicrobiology spectrum2023

Discovery of Novel Transketolase Epitopes and the Development of IgG-Based Tuberculosis Serodiagnostics.

Jaya Talreja, Changya Peng, Tuan-Minh Nguyen, Sorin Draghici, Lobelia Samavati

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Discovery of Two Novel Immunoepitopes and Development of a Peptide-based Sarcoidosis Immunoassay.American journal of respiratory and critical care medicine · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jaya Talreja *Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, Michigan, USA.
Changya Peng *Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, Michigan, USA.
Tuan-Minh NguyenDepartment of Computer Science, Wayne State University, Detroit, Michigan, USA.
Sorin DraghiciDepartment of Computer Science, Wayne State University, Detroit, Michigan, USA.
Lobelia SamavatiDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, Michigan, USA.ORCID 0000-0002-3327-2585
Wayne State University · US

Funding

Role and Regulation of MKP-1 in SarcoidosisR01HL113508 · NHLBI · WAYNE STATE UNIVERSITY · PI SAMAVATI, LOBELIA · 2013 to 2017
$1.9M
A novel T7 phage display technology to detect sarcoidosis specific antigensR01HL150474 · NHLBI · WAYNE STATE UNIVERSITY · PI SAMAVATI, LOBELIA · 2020 to 2023
$1.8M
Diagnostic classifiers for sarcoidosis using a novel T7 phage display technologyR21HL148089 · NHLBI · WAYNE STATE UNIVERSITY · PI SAMAVATI, LOBELIA · 2019 to 2020
$231k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL113508NHLBI NIH HHS R01 HL150474NHLBI NIH HHS R21 HL148089
6 · The paper itself

Abstract

Despite advances in rapid molecular techniques for tuberculosis (TB) diagnostics, there is an unmet need for a point-of-care, nonsputum-based test. Previously, through a T7 phage antigen display platform and immunoscreening, we identified that the serum IgGs of active TB patients differentially bind to several antigen-clones and that this immunoreactivity discriminates TB from other respiratory diseases. One of these high-performance clones has some homology to the transketolase of Mycobacterium tuberculosis (

Indexed as

Latent TuberculosisMycobacterium tuberculosisSarcoidosisTuberculosisAntigens, BacterialEpitopesHumansImmunoglobulin GTransketolaseAntigens, BacterialEpitopesImmunoglobulin GTransketolaseIgGMycobacterium tuberculosispeptide ELISAsarcoidosistransketolase epitopestuberculosis

Identifiers

PMID36651770
PMCPMC9927582
OpenAlexW4317213714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.