Evidence map›Paper›PMID 36651722›Full record

ArticleExperimental physiology2023

Thyroid hormone disorder and the heart: The role of cardiolipin in calcium handling.

Valentina D'Angelo, Candela Martinez, Noelia Arreche, Ana María Balaszczuk, María Del Carmen Fernández, Juan Ignacio Burgos, Martin Vila Petroff, Andrea Fellet

Open access · diamondAbstract read
In one paragraph

Article in Experimental physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Valentina D'AngeloCátedra de Fisiología, Facultad de Farmacia y Bioquímica, IQUIMEFA-CONICET, Ciudad Autónoma de Buenos Aires, Universidad de Buenos Aires, Buenos Aires, Argentina.
Candela MartinezCátedra de Fisiología, Facultad de Farmacia y Bioquímica, IQUIMEFA-CONICET, Ciudad Autónoma de Buenos Aires, Universidad de Buenos Aires, Buenos Aires, Argentina.
Noelia ArrecheCátedra de Fisiología, Facultad de Farmacia y Bioquímica, IQUIMEFA-CONICET, Ciudad Autónoma de Buenos Aires, Universidad de Buenos Aires, Buenos Aires, Argentina.
Ana María BalaszczukCátedra de Fisiología, Facultad de Farmacia y Bioquímica, IQUIMEFA-CONICET, Ciudad Autónoma de Buenos Aires, Universidad de Buenos Aires, Buenos Aires, Argentina.
María Del Carmen FernándezCátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, IQUIFIB-CONICET, Ciudad Autónoma de Buenos Aires, Universidad de Buenos Aires, Buenos Aires, Argentina.
Juan Ignacio BurgosCentro de Investigaciones Cardiovasculares Horacio Cingolani. Facultad de Ciencias Médicas, Universidad Nacional de La Plata, CONICET, La Plata, Argentina.
Martin Vila PetroffCentro de Investigaciones Cardiovasculares Horacio Cingolani. Facultad de Ciencias Médicas, Universidad Nacional de La Plata, CONICET, La Plata, Argentina.
Andrea FelletCátedra de Fisiología, Facultad de Farmacia y Bioquímica, IQUIMEFA-CONICET, Ciudad Autónoma de Buenos Aires, Universidad de Buenos Aires, Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Química y Fisicoquímica Biológicas · ARUniversidad Nacional de La Plata · ARUniversity of Buenos Aires · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Do alterations in thyroid status affect haemodynamic parameters and echocardiographic measurements in the rat postnatal heart, and calcium handling, contractility, relaxation and cardiolipin content in isolated rat cardiomyocytes? What is the main finding and its importance? An imbalance in phospholipids of the mitochondrial membrane such as cardiolipin is related to defects in mitochondrial function. T ABSTRACT: The objective of this study was to evaluate whether alterations in thyroid status affect (1) haemodynamic parameters and echocardiographic measurements in the rat postnatal heart, and (2) calcium handling, contractility, relaxation and cardiolipin content in isolated rat cardiomyocytes. Sprague-Dawley rats aged 2 months treated with T

Indexed as

CardiolipinsHypothyroidismAnimalsCalciumMyocardial ContractionMyocytes, CardiacRatsRats, Sprague-DawleySarcoplasmic ReticulumThyroid HormonesCalciumCardiolipinsThyroid Hormonescalciumcardiolipinheartthyroid hormone

Identifiers

PMID36651722
PMCPMC10103858
OpenAlexW4317360165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.