Evidence map›Paper›PMID 36651708›Full record

ArticleArchives of endocrinology and metabolism2023

Predictive factors for the diagnosis of permanent congenital hypothyroidism and its temporal changes in Sergipe, Brazil - A real-life retrospective study.

Hérika M Gumes-Felix, Roberto J R Ramalho, Enaldo V Melo, Diana M Matos, Nelmo V Menezes, Carla R P Oliveira, Viviane C Campos, Elenilde G Santos, Daniela da S Marques, Brenda Vaz Dos Santos and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hérika M Gumes-FelixDivisão de Endocrinologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Roberto J R RamalhoDepartamento de Medicina, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Enaldo V MeloDepartamento de Medicina, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Diana M MatosDivisão de Endocrinologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Nelmo V MenezesDepartamento de Medicina, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Carla R P OliveiraDivisão de Endocrinologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Viviane C CamposDivisão de Endocrinologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Elenilde G SantosDivisão de Endocrinologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Daniela da S MarquesDepartamento de Medicina, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Brenda Vaz Dos SantosDepartamento de Medicina, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Bruna M R de AndradeDepartamento de Fonoaudiologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
Manuel H Aguiar-OliveiraDivisão de Endocrinologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil, herminio@infonet.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Congenital hypothyroidism (CH) can be permanent (PCH) or transient (TCH). While the importance of thyroxine in myelination of the brain is undisputed, the benefits to neurodevelopmental outcomes of TCH treatment are controversial. Our objectives were to determine predictive factors for PCH and verify its prevalence changes over time. Subjects and methods: A total of 165 children were evaluated at 3 years of age to verify the diagnosis of PCH. 130 were submitted to a two-step cluster analysis, with the aim of grouping them into homogeneous clusters. The mean incidence of PCH and TCH was calculated from 2004 to 2010 and 2011 to 2015. Results: Sixty-six children were diagnosed with PCH, and 99 were diagnosed with TCH. Eighty-one percent of PCH children and all TCH children with thyroid imaging had glands Conclusion: The most important PCH predictors are the initial serum TSH and the blood spot TSH. The mean incidence of both PCH and TCH in our series increased.

Indexed as

Congenital HypothyroidismBrazilHumansInfant, NewbornNeonatal ScreeningRetrospective StudiesThyrotropinThyroxineThyrotropinThyroxinecongenital hypothyroidismNeonatal screeningthyrotropinthyroxine

Identifiers

PMID36651708
PMCPMC10689040

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.