Evidence map›Paper›PMID 36651644›Full record

ArticleJournal of natural products2023

Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach.

Andreas Wasilewicz, Benjamin Kirchweger, Denisa Bojkova, Marie Jose Abi Saad, Julia Langeder, Matthias Bütikofer, Sigrid Adelsberger, Ulrike Grienke, Jindrich Cinatl, Olivier Petermann and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. How does NMR support SARS-CoV-2 protein-ligand interaction studies?Analytical and bioanalytical chemistry · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Biopharmaceutical profiling of anti-infective sanggenons fromInternational journal of pharmaceutics: X · 2024
    Article
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Andreas WasilewiczDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Benjamin KirchwegerDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.ORCID 0000-0001-8948-1012
Denisa BojkovaInstitute of Medical Virology, University Hospital Frankfurt, Paul-Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany.
Marie Jose Abi SaadDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Julia LangederDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Matthias BütikoferSwiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Sigrid AdelsbergerDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.ORCID 0000-0001-7310-3199
Ulrike GrienkeDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.ORCID 0000-0003-0305-9270
Jindrich CinatlInstitute of Medical Virology, University Hospital Frankfurt, Paul-Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany.
Olivier PetermannPharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, 1205 Geneva, Switzerland.
Leonardo ScapozzaPharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, 1205 Geneva, Switzerland.
Julien OrtsDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.ORCID 0000-0003-3287-1532
Johannes KirchmairDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.ORCID 0000-0003-2667-5877
Holger F RabenauInstitute of Medical Virology, University Hospital Frankfurt, Paul-Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany.
Judith M RollingerDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.ORCID 0000-0001-6581-0774
University of Vienna · ATGoethe University Frankfurt · DEUniversity of Geneva · CHETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, an integrated in silico-in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, i.e., main protease (M

Indexed as

Biological ProductsCOVID-19Antiviral AgentsHumansMolecular Docking SimulationMorusPeptide HydrolasesProtease InhibitorsSARS-CoV-2Viral ProteasesAntiviral AgentsBiological ProductsPeptide HydrolasesProtease InhibitorsViral Proteases

Identifiers

PMID36651644
PMCPMC9885530
OpenAlexW4317212848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.