ArticleJournal of animal science2023
Enterococcus faecium from chicken feces improves chicken immune response and alleviates Salmonella infections: a pilot study.
Article in Journal of animal science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- GutiMeta · 2026Article
- Integrated omics analysis reveals the age-dependent dynamic changes of gut microbiota and metabolites in layer chickens.Poultry science · 2026Article
- Probiotic Enterococcus faecium (M74) as an alternative to antibiotics for controlling necrotic enteritis in broiler chickens.Scientific reports · 2026Article
- MitigatingMicroorganisms · 2026Review
- Postbiotic effects of Enterococcus faecium JB00008 on gut health and IBD vaccination in broiler chickens.PloS one · 2026Article
- Probiotic application to hatching egg surface supports microbiota development and acquisition in broiler embryos and hatchlings.Poultry science · 2025Article
- Article
- Probiotic and Rice-Derived Compound Combination Mitigates Colitis Severity.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Effects of Mink-OriginAnimals : an open access journal from MDPI · 2024Article
- A NewMicroorganisms · 2024Article
- Effects of dietary supplementation ofFrontiers in veterinary science · 2024Article
- The Halotolerant Probiotic BacteriumMicroorganisms · 2023Article
- Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic BacteriumMedicina (Kaunas, Lithuania) · 2023Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
Probiotics reduce the emergence of antibiotic resistance in the livestock industry. Chicken feces are reservoirs of beneficial microbiomes. The aim of this study was to isolate putative probiotics from the intestinal contents of broiler chickens. Five fecal samples were collected from two poultry farms in Al-Ahsa, Saudi Arabia. Of the 11 morphologically distinct isolates from chicken feces (CF) samples, five isolates displayed positive reactions to Gram staining, catalase, and oxidase tests, and reacted negatively to a hemolytic assay. The isolates CF1, CF2, CF3, CF8, and CF11 were selected for further analysis of probiotic characterization, gastric survival capacity, antibiotic susceptibility, and antimicrobial activity against poultry infected with Salmonella enterica. CF2 and CF11 showed the highest hydrophobic values (> 51% hydrophobic nature). CF1, CF2, and CF11 showed potent antimicrobial activities. The active isolate CF2 was identified as Enterococcus faecium by 16s rRNA sequencing and showed a genetic similarity of 99.1%. An in vivo study was conducted using a chicken model. Enterococcus faecium-fed chickens showed an improved body weight and a lower mortality rate (17-34%). Salmonella enterica colony-forming unit (CFU) invasion in the spleen and thymus was significantly reduced in the E. faecium-fed chickens. The fecal S. enterica load was reduced from CFU 6.8 to 3.9/g in oral-administered E. faecium-fed chickens. Enterococcus faecium-fed chickens showed increased levels (P < 0.01) of butyric acid and reduced levels (P < 0.01) of intestinal interleukin 1 beta, C-reactive protein, and interferon gamma levels compared to those in the S. enterica-infected chicken group. In addition, E. faecium showed significant binding to Caco-2 epithelial cells in vitro and inhibited S. enterica colonization, indicating co-aggregation of E. faecium in epithelial cells. These results revealed that an E. faecium formulation could prevent bacterial infection and improve the quality of broiler chickens.
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Registered trials
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