ArticleMedical physics2023
A conformal TOF-DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging.
Article in Medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Inter-crystal scatter recovery of a light-sharing depth-encoding Prism-PET prototype scanner using a diffusion model.Medical physics · 2026Article
- Performance of high-resolution PET detectors consisting of long GAGG slabs with different reflectors.EJNMMI physics · 2026Article
- Development of a Prototype AWSM-PET Device for Augmented Whole-Body PET Imaging and Initial Human Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Semi-Monolithic Detectors for TOF-DOI Brain PET: Optimization of Time, Energy, and Positioning Resolutions With Varying Surface Treatments.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Improved Edge Pixel Resolution in Modular PET Detectors with Partly Segmented Light Guides.Sensors (Basel, Switzerland) · 2025Article
- PET Imaging of the Human Brain with Microvolumetric Spatial Resolution.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Dual-ended readout TOF-DOI PET detectors based on 3.2 mm and 1.6 mm pitch LYSO arrays.EJNMMI physics · 2025Article
- A new design to improve time resolution in a time of flight brain PET using dual layer offset scintillator crystals.Scientific reports · 2025Article
- Depth-of-interaction encoding techniques for pixelated PET detectors enabled by machine learning methods and fast waveform digitization.Physics in medicine and biology · 2025Article
- Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Fast high-resolution lifetime image reconstruction for positron lifetime tomography.Communications physics · 2025Article
- Recent advances in radionuclide medical imaging techniques.Frontiers in medicine · 2025Review
- High-resolution motion compensation for brain PET imaging using real-time electromagnetic motion tracking.Medical physics · 2025Article
- Enhanced Timing Performance of Dual-Ended PET Detectors for Brain Imaging Using Dual-Finishing Crystal Approach.Sensors (Basel, Switzerland) · 2024Article
- Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Depth-encoding using optical photon TOF in a prism-PET detector with tapered crystals.Medical physics · 2024Article
- DOI- and TOF-capable PET array detector using double-ended light readout and stripline-based row and column electronic readout.IEEE transactions on radiation and plasma medical sciences · 2024Article
- Resolving inter-crystal scatter in a light-sharing depth-encoding PET detector.Physics in medicine and biology · 2024Article
- New Horizons in Brain PET Instrumentation.PET clinics · 2024Review
- The quest for multifunctional and dedicated PET instrumentation with irregular geometries.Annals of nuclear medicine · 2024Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPositron emission tomography (PET) has had a transformative impact on oncological and neurological applications. However, still much of PET's potential remains untapped with limitations primarily driven by low spatial resolution, which severely hampers accurate quantitative PET imaging via the partial volume effect (PVE). PURPOSE: We present experimental results of a practical and cost-effective ultra-high resolution brain-dedicated PET scanner, using our depth-encoding Prism-PET detectors arranged along a compact and conformal gantry, showing substantial reduction in PVE and accurate radiotracer uptake quantification in small regions.
methodsThe decagon-shaped prototype scanner has a long diameter of 38.5 cm, a short diameter of 29.1 cm, and an axial field-of-view (FOV) of 25.5 mm with a single ring of 40 Prism-PET detector modules. Each module comprises a 16 × 16 array of 1.5 × 1.5 × 20-mm
resultsThe full width at half maximum (FWHM) DOI, energy, and timing resolutions of the scanner are 2.85 mm, 12.6%, and 271 ps, respectively. Not considering artifacts due to mechanical misalignment of detector blocks, the intrinsic spatial resolution is 0.89-mm FWHM. Point source images reconstructed with 3D filtered back-projection (FBP) show an average spatial resolution of 1.53-mm FWHM across the entire FOV. The peak absolute sensitivity is 1.2% for an energy window of 400-650 keV. The ultra-micro Derenzo phantom study demonstrates the highest reported spatial resolution performance for a human brain PET scanner with perfect reconstruction of 1.00-mm diameter hot-rods. Reconstructed images of customized Hoffman brain phantoms prove that Prism-PET enables accurate radiotracer uptake quantification in small brain regions (2-3 mm).
conclusionsPrism-PET will substantially strengthen the utility of quantitative PET in neurology for early diagnosis of neurodegenerative diseases, and in neuro-oncology for improved management of both primary and metastatic brain tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.