Evidence map›Paper›PMID 36651544›Full record

ArticleActa pharmaceutica (Zagreb, Croatia)2022

Bivalirudin exerts antiviral activity against respiratory syncytial virus-induced lung infections in neonatal mice.

Shihao Zhuang, Qiuyu Tang, Ping Chen, Chengyi Wang, Guanghua Liu

Open access · goldAbstract read
PubMed Publisher
In one paragraph

Article in Acta pharmaceutica (Zagreb, Croatia), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Shihao ZhuangDepartment of Pediatrics, Fujian Children's Hospital, Fuzhou, Fujian China, 350000.
Qiuyu TangDepartment of Pediatrics, Fujian Children's Hospital, Fuzhou, Fujian China, 350000.
Ping ChenDepartment of Medical Administration Fujian Children's Hospital, Fuzhou Fujian, China, 350000.
Chengyi WangDepartment of Pediatrics, Fujian Children's Hospital, Fuzhou, Fujian China, 350000.
Guanghua LiuDepartment of Pediatrics, Fujian Children's Hospital, Fuzhou, Fujian China, 350000.
Fujian Women and Children Hospital · CNFujian Medical University · CNFuzhou Maternity and Child Health Care Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is the most common cause of small airways inflammation in the lungs (bronchiolitis) in neonates and immunocompromised adults. The deregulation of cellular and plasma components leads to increased morbidity and mortality. The activation of the clotting cascade plays a key role in the progression of disease severity during viral infection. The current investigation studied the effect of bivalirudin (BR) on the progression and cellular effects of RSV-induced infection in the neonatal mice model. Mice (5-7 days old) were inoculated intranasally with RSV with or without BR administration (2 mg kg

Indexed as

MicroRNAsRespiratory Syncytial Virus InfectionsAnimalsAnimals, NewbornAntiviral AgentsCytokinesDisease Models, AnimalHirudinsLungMiceMice, Inbred BALB CPeptide FragmentsRecombinant ProteinsRespiratory Syncytial VirusesAntiviral AgentsbivalirudinCytokinesHirudinsMicroRNAsPeptide FragmentsRecombinant Proteinsbivalirudininflammatory cytokinesmiceneonatesrespiratory syncytial virus

Identifiers

PMID36651544
OpenAlexW4223903920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.