Evidence map›Paper›PMID 36651249›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Knockout of S1PR3 attenuates acute lung injury in mice by inhibiting the MAPK pathway].

S Fang, R Yuan, R Sun, T Ma

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

S FangSchool of Anesthesiology, Wannan Medical College, Wuhu 241002, China.
R YuanSchool of Anesthesiology, Wannan Medical College, Wuhu 241002, China.
R SunSchool of Anesthesiology, Wannan Medical College, Wuhu 241002, China.
T MaCollege of Forensic Medicine, Wannan Medical College, Wuhu 241002, China.
Wannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether knockout of S1PR3 improves lipopolysaccharide (LPS)-induced acute lung injury in mice by inhibiting mitogen activated protein kinases (MAPKs).

methodsMale C57BL/6J and S1PR3 knockout (S1PR3

resultsThe expression of S1PR3 was up-regulated and serum IL-1β and IL-18 levels were elevated significantly in the nontransgenic mice with acute lung injury (

conclusionInhibition of S1PR3 can improve LPSinduced acute lung injury in mice by inhibiting the activation of MAPK signaling.

Indexed as

Acute Lung InjuryMAP Kinase Signaling SystemSphingosine-1-Phosphate ReceptorsAnimalsCaspasesInterleukin-18LipopolysaccharidesLungMaleMiceMice, Inbred C57BLMice, KnockoutCaspasesInterleukin-18LipopolysaccharidesS1pr3 protein, mouseSphingosine-1-Phosphate Receptorsacute lung injurycell pyroptosisCYM5541MAPK pathwayS1PR3

Identifiers

PMID36651249
PMCPMC9878423
OpenAlexW4317360497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.