Evidence map›Paper›PMID 36651179›Full record

ArticleACS chemical neuroscience2023

Design of Analgesic Trivalent Peptides with Low Withdrawal Symptoms: Probing the Antinociceptive Profile of Novel Linear and Cyclic Peptides as Opioid Pan Ligands.

Azzurra Stefanucci, Paola Minosi, Stefano Pieretti, Parthasaradhireddy Tanguturi, Gabriella Molnar, Giuseppe Scioli, Lorenza Marinaccio, Alice Della Valle, John M Streicher, Adriano Mollica

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Azzurra StefanucciDipartimento di Farmacia, Universitá; di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.ORCID 0000-0001-7525-2913
Paola MinosiCentro Nazionale Ricerca e Valutazione Preclinica e Clinica dei Farmaci, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
Stefano PierettiCentro Nazionale Ricerca e Valutazione Preclinica e Clinica dei Farmaci, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0001-5926-6194
Parthasaradhireddy TanguturiDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85012, United States.
Gabriella MolnarDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85012, United States.
Giuseppe ScioliDipartimento di Farmacia, Universitá; di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
Lorenza MarinaccioDipartimento di Farmacia, Universitá; di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
Alice Della ValleDipartimento di Farmacia, Universitá; di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
John M StreicherDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85012, United States.
Adriano MollicaDipartimento di Farmacia, Universitá; di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.ORCID 0000-0002-7242-4860
University of Chieti-Pescara · ITUniversity of Arizona · USIstituto Superiore di Sanità · IT

Funding

Development of Hsp90 Isoform- Selective Inhibitors as a Novel Opioid Dose-Reduction TherapyR01DA052340 · NIDA · UNIVERSITY OF ARIZONA · PI STREICHER, JOHN MICHAEL · 2021 to 2025
$3.3M
NIDA NIH HHS R01 DA052340
6 · The paper itself

Abstract

The discovery of efficacious and safe analgesics with reduced side effects is the foremost challenge in the pain field. In this work, we report the

Indexed as

Analgesics, OpioidPeptides, CyclicAnalgesicsHumansHyperalgesiaLigandsOpioid PeptidesReceptors, Opioid, muAnalgesicsAnalgesics, OpioidLigandsOpioid PeptidesPeptides, CyclicReceptors, Opioid, mubiphalinnociceptionopioidpan ligandspeptideswithdrawal

Identifiers

PMID36651179
PMCPMC12005346
OpenAlexW4317207978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.