ArticleFEBS open bio2023
Zebrafish and medaka T1R (taste receptor type 1) proteins mediate highly sensitive recognition of l-proline.
Article in FEBS open bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Dietary responses of taste receptor genes to plant-based diets in farmed fish: A literature review.Open veterinary journal · 2026Review
- Article
- Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular chloride ion.Scientific reports · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
In vertebrates, nutritional tastants, such as amino acids and sugars, are recognized by G-protein-coupled receptors of the taste receptor type 1 (T1R) family. Previous studies have shown that fish T1Rs are functionally distinct from mammalian T1Rs in certain regards. Here, we report the existence of oral receptors with high sensitivity to amino acids in zebrafish and medaka fish. We describe the construction of multiple cell lines stably expressing functional T1Rs (from medaka fish or zebrafish) with a chimeric G-protein (G16gust44) using the Flp-In system. Through functional assays with these cell lines, medaka fish and zebrafish were confirmed to possess particular T1Rs highly sensitive to l-proline, possibly reflecting the physiological importance of l-proline in teleosts, in line with previous studies.
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