Evidence map›Paper›PMID 36651047›Full record

ArticleProceedings. Biological sciences2023

Diagnosis of helminths depends on worm fecundity and the distribution of parasites within hosts.

Thomas Crellen, Melissa Haswell, Paiboon Sithithaworn, Somphou Sayasone, Peter Odermatt, Poppy H L Lamberton, Simon E F Spencer, T Déirdre Hollingsworth

Open access · hybridAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Natural history of liver fluke infection underpins epidemiological patterns of biliary cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Modelling morbidity for neglected tropical diseases: the long and winding road from cumulative exposure to long-term pathology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Thomas CrellenSchool of Biodiversity One Health and Veterinary Medicine, Graham Kerr Building, University of Glasgow, 82 Hillhead Street, Glasgow G12 8QQ, UK.ORCID 0000-0003-2934-1063
Melissa HaswellOffice of the Deputy Vice Chancellor, Indigenous Strategy and Services and School of Geosciences, John Woolley Building, University of Sydney, Sydney, New South Wales 2050, Australia.ORCID 0000-0002-4067-7951
Paiboon SithithawornDepartment of Parasitology, Khon Kaen University, 123 Thanon Mittraphap, Khon Kaen 40002, Thailand.ORCID 0000-0002-9480-1778
Somphou SayasoneLao Tropical and Public Health Institute, Samsenthai Road, Sisattanak district, Vientiane, Lao PDR.ORCID 0000-0001-8219-9567
Peter OdermattDepartment of Public Health and Epidemiology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, Allschwil 4123, Switzerland.ORCID 0000-0002-0296-2508
Poppy H L LambertonSchool of Biodiversity One Health and Veterinary Medicine, Graham Kerr Building, University of Glasgow, 82 Hillhead Street, Glasgow G12 8QQ, UK.ORCID 0000-0003-1048-6318
Simon E F SpencerDepartment of Statistics, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0002-8375-5542
T Déirdre HollingsworthBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK.ORCID 0000-0001-5962-4238
University of Oxford · GBKhon Kaen University · THPublic Health Institute · USSwiss Tropical and Public Health Institute · CHThe University of Sydney · AUUniversity of Warwick · GBWellcome Centre for Molecular Parasitology · GB

Funding

Wellcome TrustWellcome Trust 215919/B/19/Z
6 · The paper itself

Abstract

Helminth transmission and morbidity are dependent on the number of mature parasites within a host; however, observing adult worms is impossible for many natural infections. An outstanding challenge is therefore relating routine diagnostics, such as faecal egg counts, to the underlying worm burden. This relationship is complicated by density-dependent fecundity (egg output per worm reduces due to crowding at high burdens) and the skewed distribution of parasites (majority of helminths aggregated in a small fraction of hosts). We address these questions for the carcinogenic liver fluke

Indexed as

HelminthsParasitesTrematodaAnimalsFecesFertilityParasite Egg CountBayesian inferenceepidemiologyfoodborne trematodiasesmacroparasiteneglected tropical diseases

Identifiers

PMID36651047
PMCPMC9845982
OpenAlexW4317360780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.