Evidence map›Paper›PMID 36651002›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2023

A Highly Translatable Dual-arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor-bearing Brain Tissues.

Karina Negron, Gijung Kwak, Heng Wang, Haolin Li, Yi-Ting Huang, Shun-Wen Chen, Betty Tyler, Charles G Eberhart, Justin Hanes, Jung Soo Suk

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Karina NegronCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Gijung KwakCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID 0000-0001-6908-9638
Heng WangDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Haolin LiDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Yi-Ting HuangDepartment of Neuroscience and Behavioral Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Shun-Wen ChenDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Betty TylerDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID 0000-0001-9800-6969
Charles G EberhartDepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID 0000-0002-2910-9427
Justin HanesCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Jung Soo SukCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID 0000-0002-2437-0001
Johns Hopkins University · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
Innovative systemic gene therapy for treating Parkinson's diseaseR01NS111102 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI PRICE, RICHARD J., SUK, JUNG SOO · 2019 to 2023
$2.6M
Targeted Delivery of Brain Penetrating DNA Nanoparticles to Brain TumorsR01CA204968 · NCI · JOHNS HOPKINS UNIVERSITY · PI HANES, JUSTIN S., SUK, JUNG SOO · 2016 to 2020
$2.5M
Nanocage-based systemic delivery of TGFβ trap for immunomodulation of brain neoplasmsR01NS119609 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIM, MICHAEL, SUK, JUNG SOO · 2021 to 2025
$2.4M
Focused ultrasound pre-conditioning for augmented nanoparticle penetration in infiltrative gliomasR01EB030409 · NIBIB · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2021 to 2024
$2.3M
NCI NIH HHS R01 CA204968NEI NIH HHS P30 EY001765NIBIB NIH HHS R01 EB030409NINDS NIH HHS R01 NS111102NINDS NIH HHS R01 NS119609
6 · The paper itself

Abstract

Drug delivery nanoparticles (NPs) based entirely on materials generally recognized as safe that provide widespread parenchymal distribution following intracranial administration via convection-enhanced delivery (CED) are introduced. Poly(lactic-co-glycolic acid) (PLGA) NPs are coated with various poloxamers, including F68, F98, or F127, via physical adsorption to render particle surfaces non-adhesive, thereby resisting interactions with brain extracellular matrix. F127-coated PLGA (F127/PLGA) NPs provide markedly greater distribution in healthy rat brains compared to uncoated NPs and widespread coverage in orthotopically-established brain tumors. Distribution analysis of variously-sized F127/PLGA NPs determines the average rat brain tissue porosity to be between 135 and 170 nm while revealing unprecedented brain coverage of larger F127/PLGA NPs with an aid of hydraulic pressure provided by CED. Importantly, F127/PLGA NPs can be lyophilized for long-term storage without compromising their ability to penetrate the brain tissue. Further, 65- and 200-nm F127/PLGA NPs lyophilized-reconstituted and administered in a moderately hyperosmolar infusate solution show further enhance particle dissemination in the brain via osmotically-driven enlargement of the brain tissue porosity. Combination of F127/PLGA NPs and osmotic tissue modulation provides a means with a clear regulatory path to maximize the brain distribution of large NPs that enable greater drug loading and prolong drug release.

Indexed as

NanoparticlesNeoplasmsAnimalsBrainDrug CarriersLactic AcidParticle SizePolyethylenesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolypropylenesRatsDrug CarriersLactic AcidPolyethylenesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolypropylenesUCON 50-HB-5100brain extracellular spacedrug delivery nanoparticlesextracellular matrix (ECM) modulationinfusate osmolalitylocal infusion

Identifiers

PMID36651002
PMCPMC10082594
OpenAlexW4317105982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.