ArticleAging cell2023
The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA).
Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Epigenetic Age Acceleration as a Modifiable Public Health Target: A Systematic Review and Meta-Analysis of Environmental, Behavioral, and Social Determinants with Development of the MEAB-Index.International journal of molecular sciences · 2026Pooled it
- The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.Clinical epigenetics · 2026Pooled it
- Measuring intrinsic capacity among Canadian adults: a population-based study using the Canadian Longitudinal Study on Aging (CLSA).Lancet regional health. Americas · 2026Article
- Advancing child health: forecasting the next great research achievements.Pediatric research · 2026Article
- Early-life determinants of cardiometabolic outcomes and accelerated biological ageing in Colombia.Aging · 2026Article
- Interpersonal adversity and health across the life course.Current opinion in psychology · 2026Review
- Effects of intergenerational parent-child separation on early eruption of permanent molar and telomere length: a cross-sectional study among Chinese children aged 3-6 years.BMC oral health · 2026Article
- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- The role of stress proliferation in linking childhood stressors to accelerated biological aging.Social science & medicine (1982) · 2025Article
- Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos.Epigenomics · 2025Article
- Prenatal exposure to genocide accelerates epigenetic aging in third- and fourth-generation clocks among young adults in Rwanda.Communications medicine · 2025Article
- Causal Mediation Analysis for the Intergenerational Transmission of Violence Reveals Pathways From Child Maltreatment to Elder Mistreatment.The Gerontologist · 2025Observational
- Negative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register.Behavior genetics · 2025Article
- Longitudinal associations between early-life adversity and accelerated molar eruption: the dimensional and cumulative approach.BMC oral health · 2025Article
- Adverse Childhood Experiences and Accelerated Epigenetic Aging in the Hispanic Community Health Study/Study of Latinos: Nativity as an Effect Modifier.Psychoneuroendocrinology · 2025Article
- Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31-year follow-up.Aging cell · 2025Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Lifetime chronic stress exposures, stress hormones, and biological aging: Results from the Midlife in the United States (MIDUS) study.Brain, behavior, and immunity · 2025Article
- Stressful life events across the lifespan and inflammation: An integrative data analysis.Brain, behavior, & immunity - health · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Research examining the association between exposure to a wide range of adverse childhood experiences (ACEs) and accelerated biological aging in older adults is limited. The purpose of this study was to examine the association of ACEs, both as a cumulative score and individual forms of adversity, with epigenetic age acceleration assessed using the DNA methylation (DNAm) GrimAge and DNAm PhenoAge epigenetic clocks in middle and older-aged adults. This cross-sectional study analyzed baseline and first follow-up data on 1445 participants aged 45-85 years from the Canadian Longitudinal Study on Aging (CLSA) who provided blood samples for DNAm analysis. ACEs were assessed using a validated self-reported questionnaire. Epigenetic age acceleration was estimated by regressing each epigenetic clock estimate on chronological age. Cumulative ACEs score was associated with higher DNAm GrimAge acceleration (β: 0.07; 95% CI: 0.02, 0.11) after adjusting for covariates. Childhood exposure to parental separation or divorce (β: 0.06; 95% CI: 0.00, 0.11) and emotional abuse (β: 0.06; 95% CI: 0.00, 0.12) were associated with higher DNAm GrimAge acceleration after adjusting for other adversities and covariates. There was no statistical association between ACEs and DNAm PhenoAge acceleration. Early life adversity may become biologically embedded and lead to premature biological aging, in relation to DNAm GrimAge, which estimates risk of mortality. Strategies that increase awareness of ACEs and promote healthy child development are needed to prevent ACEs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.