Evidence map›Paper›PMID 36650607›Full record

ArticleBiotechnology for biofuels and bioproducts2023

Bioconversion of non-food corn biomass to polyol esters of fatty acid and single-cell oils.

Guang-Lei Liu, Xian-Ying Bu, Chaoyang Chen, Chunxiang Fu, Zhe Chi, Akihiko Kosugi, Qiu Cui, Zhen-Ming Chi, Ya-Jun Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biotechnology for biofuels and bioproducts, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Guang-Lei Liu *College of Marine Life Sciences, Ocean University of China, Qingdao, 266101, People's Republic of China.
Xian-Ying Bu *College of Marine Life Sciences, Ocean University of China, Qingdao, 266101, People's Republic of China.
Chaoyang ChenCAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.
Chunxiang FuCAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.
Zhe ChiCollege of Marine Life Sciences, Ocean University of China, Qingdao, 266101, People's Republic of China.
Akihiko KosugiBiological Resources and Post-Harvest Division, Japan International Research Center for Agricultural Sciences (JIRCAS), 1-1 Ohwashi, Tsukuba, Ibaraki, Japan.
Qiu CuiCAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.
Zhen-Ming ChiCollege of Marine Life Sciences, Ocean University of China, Qingdao, 266101, People's Republic of China.
Ya-Jun LiuCAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China. liuyj@qibebt.ac.cn.
Ocean University of China · CNChinese Academy of Sciences · CNDalian National Laboratory for Clean Energy · CNJapan International Research Center for Agricultural Sciences · JPQingdao Institute of Bioenergy and Bioprocess Technology · CNQingdao National Laboratory for Marine Science and Technology · CNUniversity of Chinese Academy of Sciences · CN

Funding

National Key Research and Development Program of China 2021YFC2103200, 2021YFC2103600National Natural Science Foundation of China 31970069, 32070028, 32170051QIBEBT Research Foundation QIBEBT ZZBS 201801Qingdao Innovation Major Project 21-1-2-23-hzShandong Energy Institute Research Foundation SEI S202106, SEI I202142State Key Laboratory of Microbial Technology Open Projects Fund M2021-03Strategic Priority Research Program of the Chinese Academy of Sciences XDA 21060201
6 · The paper itself

Abstract

backgroundLignocellulose is a valuable carbon source for the production of biofuels and biochemicals, thus having the potential to substitute fossil resources. Consolidated bio-saccharification (CBS) is a whole-cell-based catalytic technology previously developed to produce fermentable sugars from lignocellulosic agricultural wastes. The deep-sea yeast strain Rhodotorula paludigena P4R5 can produce extracellular polyol esters of fatty acids (PEFA) and intracellular single-cell oils (SCO) simultaneously. Therefore, the integration of CBS and P4R5 fermentation processes would achieve high-value-added conversion of lignocellulosic biomass.

resultsThe strain P4R5 could co-utilize glucose and xylose, the main monosaccharides from lignocellulose, and also use fructose and arabinose for PEFA and SCO production at high levels. By regulating the sugar metabolism pathways for different monosaccharides, the strain could produce PEFA with a single type of polyol head. The potential use of PEFA as functional micelles was also determined. Most importantly, when sugar-rich CBS hydrolysates derived from corn stover or corncob residues were used to replace grain-derived pure sugars for P4R5 fermentation, similar PEFA and SCO productions were obtained, indicating the robust conversion of non-food corn plant wastes to high-value-added glycolipids and lipids. Since the produced PEFA could be easily collected from the culture via short-time standing, we further developed a semi-continuous process for PEFA production from corncob residue-derived CBS hydrolysate, and the PEFA titer and productivity were enhanced up to 41.1 g/L and 8.22 g/L/day, respectively.

conclusionsHere, we integrated the CBS process and the P4R5 fermentation for the robust production of high-value-added PEFA and SCO from non-food corn plant wastes. Therefore, this study suggests a feasible way for lignocellulosic agro-waste utilization and the potential application of P4R5 in industrial PEFA production.

Indexed as

GlycolipidsLignocellulosePolyol esters of fatty acidsSaccharificationYeast fermentation

Identifiers

PMID36650607
PMCPMC9844004
OpenAlexW4316813187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.