Evidence map›Paper›PMID 36650593›Full record

Trial reportCritical care (London, England)2023

Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial.

Jose Victor Jimenez, Elizabeth Munroe, Andrew J Weirauch, Kelly Fiorino, Christopher A Culter, Kristine Nelson, Wassim W Labaki, Philip J Choi, Ivan Co, Theodore J Standiford and 2 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03793842 nacompletednot on this map

Use of Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure in Acute Respiratory Distress Syndrome

TypeinterventionalSponsorUniversity of MichiganRan2019 to 2022Enrolled16ConditionsAcute Respiratory Distress Syndrome, ARDSArmsUsual care, PEEP titration by EIT
NCT07184580 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Electrical Impendance Tomography Usage in ICU : Registry Creation

Typeobservational_patient_registrySponsorErasme University HospitalRan2025 to 2031Enrolled1,000ConditionsARDS, Alveolar Recruitment Manoeuvres, Prone Position, Electrical Impedance Tomography (EIT)
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Enhancement of Pulmonary Function and Reduction of Complications Through EIT-Guided Yoga Breathing Exercise After Esophagectomy.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Trial
  10. Article
  11. Review
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  13. The role of mechanical power in lung ventilation for the prevention of ventilator-induced lung injury: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jose Victor JimenezDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Elizabeth MunroeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Andrew J WeirauchUH/CVC Department of Respiratory Care, University of Michigan, Ann Arbor, MI, USA.
Kelly FiorinoUH/CVC Department of Respiratory Care, University of Michigan, Ann Arbor, MI, USA.
Christopher A CulterUH/CVC Department of Respiratory Care, University of Michigan, Ann Arbor, MI, USA.
Kristine NelsonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Philip J ChoiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Ivan CoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Theodore J StandifordDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Hallie C PrescottDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA.
Robert C HyzyDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Dr. Floor 3 Reception C, Ann Arbor, MI, 48109, USA. rhyzy@med.umich.edu.

Funding

PULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9M
NHLBI NIH HHS T32 HL007749
6 · The paper itself

Abstract

backgroundIn patients with acute respiratory distress syndrome undergoing mechanical ventilation, positive end-expiratory pressure (PEEP) can lead to recruitment or overdistension. Current strategies utilized for PEEP titration do not permit the distinction. Electric impedance tomography (EIT) detects and quantifies the presence of both collapse and overdistension. We investigated whether using EIT-guided PEEP titration leads to decreased mechanical power compared to high-PEEP/FiO2 tables.

methodsA single-center, randomized crossover pilot trial comparing EIT-guided PEEP selection versus PEEP selection using the High-PEEP/FiO

resultsEIT was consistently associated with a decrease in mechanical power compared to PEEP/FiO

conclusionsIn patients with moderate-severe acute respiratory distress syndrome, EIT-guided PEEP titration reduces mechanical power mainly through a reduction in elastic-dynamic power. Trial registration This trial was prospectively registered on Clinicaltrials.gov (NCT03793842) on January 4th, 2019.

Indexed as

Respiratory Distress SyndromeElectric ImpedanceHumansPilot ProjectsPositive-Pressure RespirationTomographyAcute lung injuryElectrical impedance tomographyMechanical ventilatorsRespiratory distress syndromeVentilator-induced lung injury

Identifiers

PMID36650593
PMCPMC9843117

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.