Evidence map›Paper›PMID 36650548›Full record

SynthesisJournal of cardiothoracic surgery2023

Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis.

Kang Yi, Jie Gao, Wen-Xin Wang, Yu-Hu Ma, Wei Wang, Shao E He, Xiao-Min Xu, Peng-Fei Li, Tao You

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cardiothoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Transcatheter mitral and tricuspid therapy: outcomes in female patients.Indian journal of thoracic and cardiovascular surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kang Yi *Department of Cardiovascular Surgery, Gansu Province, Gansu Provincial Hospital, No. 204, Donggang West Road, Lanzhou, 730000, China.
Jie Gao *Gansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart Disease, Lanzhou, China.
Wen-Xin WangGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart Disease, Lanzhou, China.
Yu-Hu MaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Wei WangDepartment of Cardiac Surgery, The First Hospital of China Medical University, Shenyang, China.
Shao E HeGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart Disease, Lanzhou, China.
Xiao-Min XuGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart Disease, Lanzhou, China.
Peng-Fei LiGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart Disease, Lanzhou, China.
Tao YouDepartment of Cardiovascular Surgery, Gansu Province, Gansu Provincial Hospital, No. 204, Donggang West Road, Lanzhou, 730000, China. youtao2016@126.com.
China International Science and Technology Cooperation · CNSun Yat-sen University · CNSichuan University · CN

Funding

Health industry scientific research project of Gansu Province GSWSKY2016-04Science Foundation of Gansu Province 21JR1RA027
6 · The paper itself

Abstract

backgroundThe effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of studies that investigate differences between men and women after TMVR.

methodsA systematic literature search was carried out on eight databases to collect all relevant studies on gender-related outcomes of TMVR before March 1, 2021. The main outcomes of interest were mortality, cardiac function, MR class and other complications.

resultsA total of eight literatures were included, all of which were retrospective observational studies. Compared to women patients, men had lower postoperative New York Heart Association (NYHA) class (OR = 1.53, 95%CI [1.23, 1.91], P = 0.0001) and higher incidence of postoperative acute kidney injury (AKI) (OR = 1.25, 95%CI [1.16, 1.34], P < 0.05). There were no significant difference on mortality in 30 days (OR = 0.95, 95%CI [0.81, 1.11], P = 0.53) and in 2 years (OR = 0.99, 95%CI [0.75, 1.30], P = 0.93), mitral valve regurgitation (MR) class (OR = 1.30, 95%CI [0.97, 1.75], P = 0.08) and incidence of myocardial infarction (MI) (OR = 0.88, 95%CI [0.65, 1.18], P = 0.38), stroke (OR = 0.80, 95%CI [0.63, 1.02], P = 0.08) and bleeding in hospital (OR = 0.84, 95%CI [0.59, 1.19], P = 0.32).

conclusionsOur meta-analysis demonstrates that men undergoing TMVR have worse preoperative diseases (diabetes mellitus, coronary artery disease, renal failure and myocardial infarction) while they have superior postoperative NYHA class at one-year. There are no significantly difference in other indexes between men and women.

Indexed as

Heart Valve Prosthesis ImplantationMitral Valve InsufficiencyMyocardial InfarctionCardiac CatheterizationFemaleHumansMaleMitral ValveRetrospective StudiesTreatment OutcomeGender differencesMeta-analysisMitraClipMitral valve regurgitationSystematic reviewsTranscatheter mitral valve repair

Identifiers

PMID36650548
PMCPMC9843892
OpenAlexW4316810636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.