ArticleBMC oral health2023
Oral microbiome contributes to the failure of orthodontic temporary anchorage devices (TADs).
Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Orthodontic treatment and oral microbiota changes: a systematic review of oral dysbiosis revealed by 16S rRNA gene analysis.The Angle orthodontist · 2025Pooled it
- Clinical Performance of Infrazygomatic Crest Miniscrews Placed Without Surgical Guides: A Retrospective Study with 30-Month Follow-Up.Bioengineering (Basel, Switzerland) · 2026Article
- Assessing the relationship between mini-screw implant shape and primary stability: An experimental study in orthodontics.Journal of orthodontic science · 2026Article
- Clinical Management of Orthodontic Miniscrew Complications: A Scoping Review.Dentistry journal · 2025Review
- Methods of Orthodontic Microimplant Surface Modifications Providing Antibacterial Properties: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- Cone-beam computed tomography evaluation of root proximity of miniscrew implant and its correlation with failure.BMC oral health · 2025Article
- Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis.BMC oral health · 2025Article
- Dynamics of the oral microbiome during orthodontic treatment and antimicrobial advances for orthodontic appliances.iScience · 2024Review
- Genetic Testing as a Source of Information Driving Diagnosis and Therapeutic Plan in a Multidisciplinary Case.Bioengineering (Basel, Switzerland) · 2024Article
- The Orthodontic Mini-Implants Failures Based on Patient Outcomes: Systematic Review.European journal of dentistry · 2024Article
- Analysis of oral microbiome on temporary anchorage devices under different periodontal conditions.Progress in orthodontics · 2023Article
- Microbial flora surrounding orthodontic temporary skeletal anchorage devices: A systematic review.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe stability of temporary anchorage devices (TADs) is critical in orthodontic clinics. The failure of TADs is multifactorial, and the role of the oral microbiome has not been clearly defined. Herein, we attempted to analyze the contribution of the oral microbiome to the failure of TADs.
methodsNext-generation sequencing was adopted for analyzing the microbiome on the TADs from orthodontic patients. 29 TADs (15 failed TADs and 14 successful TADs) were used for 16S rRNA gene sequencing. A total of 135 TADs (62 failed TADs and 73 successful TADs) were collected to conduct metagenomic sequencing. Additionally, 34 verified samples (18 failed TADs and 16 successful TADs) were collected for quantitative real-time polymerase chain reaction analysis (qRT-PCR).
resultsSuccessful and failed TADs demonstrated discrepancies in microbiome structure, composition, and function. Clear separations were found in β-diversity in 16S rRNA gene sequencing as well as metagenomic sequencing (p < 0.05). Metagenomic sequencing showed that Prevotella intermedia, Eikenella corrodens, Parvimonas spp., Neisseria elongata, and Catonella morbi were enriched in the failed groups. qRT-PCR also demonstrated that the absolute bacteria load of Prevotella intermedia was higher in failed TADs (p < 0.05). Considering functional aspects, the failed group showed enriched genes involved in flagellar assembly, bacterial chemotaxis, and oxidative phosphorylation.
conclusionsThis study illustrated the compositional and functional differences of microorganisms found on successful and failed TADs, indicating that controlling bacterial adhesion on the surface of TADs is essential for their success rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.