Evidence map›Paper›PMID 36650519›Full record

ArticleCell division2023

Circular RNA hsa_circ_0075323 promotes glioblastoma cells proliferation and invasion via regulation of autophagy.

Wenrui Zhang, Zhonggang Shi, Shouren Chen, Shaoshan Shen, Songjie Tu, Jian Yang, Yongming Qiu, Yingying Lin, Xuejun Dai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell division, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  5. Regulation of autophagy by non-coding RNAs in human glioblastoma.Medical oncology (Northwood, London, England) · 2024
    Review
  6. The Glioblastoma CircularRNAome.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wenrui Zhang *Brain Injury Center, Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Room 1626, Building 17, 1630 Dongfang Road, Pudong Distric, Shanghai, 200127, People's Republic of China.
Zhonggang Shi *Brain Injury Center, Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Room 1626, Building 17, 1630 Dongfang Road, Pudong Distric, Shanghai, 200127, People's Republic of China.
Shouren ChenDepartment of Neurosurgery, Zhangzhou Affiliated Hospital of Fujian Medical University, NO. 59th West Shengli Road, Zhangzhou, 363000, China.
Shaoshan ShenDepartment of Neurosurgery, Zhangzhou Affiliated Hospital of Fujian Medical University, NO. 59th West Shengli Road, Zhangzhou, 363000, China.
Songjie TuDepartment of Neurosurgery, Zhangzhou Affiliated Hospital of Fujian Medical University, NO. 59th West Shengli Road, Zhangzhou, 363000, China.
Jian YangBrain Injury Center, Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Room 1626, Building 17, 1630 Dongfang Road, Pudong Distric, Shanghai, 200127, People's Republic of China.
Yongming QiuBrain Injury Center, Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Room 1626, Building 17, 1630 Dongfang Road, Pudong Distric, Shanghai, 200127, People's Republic of China.
Yingying LinBrain Injury Center, Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Room 1626, Building 17, 1630 Dongfang Road, Pudong Distric, Shanghai, 200127, People's Republic of China. yylin@sibs.ac.cn.
Xuejun DaiDepartment of Neurosurgery, Zhangzhou Affiliated Hospital of Fujian Medical University, NO. 59th West Shengli Road, Zhangzhou, 363000, China. dai_doc@163.com.
Shanghai Jiao Tong University · CNFujian Medical University · CNZhangzhou Municipal Hospital of Fujian Province · CN

Funding

National Science Foundation of Fujian Province 2018J1210
6 · The paper itself

Abstract

backgroundProtein p62 (sequestosome 1) encoded by gene SQSTM1 plays a vital role in mediating protectively selective autophagy in tumor cells under stressed conditions. CircSQSTM1 (hsa_circ_0075323) is a circular transcript generated from gene SQSTM1 (chr5:179260586-179260782) by back-splicing. However, the potential role of hsa_hsa_circ_0075323 in glioblastoma (GBM) remains unclear. Here, we aimed to explore the biological function of hsa_circ_0075323 in GBM and its relationship with autophagy regulation.

resultsHsa_circ_0075323 is highly expressed in GBM cells and mainly locates in the cytoplasm. Inhibition of hsa_circ_0075323 in U87-MG and T98G cells attenuated proliferation and invasion ability significantly, while upregulation of has_ circ_0075323 enhanced proliferation and migration of U251-MG and A172 cells. Mechanistically, depletion of hsa_circ_0075323 in GBM cells resulted in impaired autophagy, as indicated by increased expression of p62 and decreased expression of LC3B.

conclusionsHsa_circ_0075323 regulates p62-mediated autophagy pathway to promote GBM progression and may serve as a prognostic biomarker potentially.

Indexed as

AutophagyGlioblastomahsa_circ_0075323InvasionProliferation

Identifiers

PMID36650519
PMCPMC9843830
OpenAlexW4316812920

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.