Evidence map›Paper›PMID 36650517›Full record

ArticleJournal of nanobiotechnology2023

A pH-responsive metal-organic framework for the co-delivery of HIF-2α siRNA and curcumin for enhanced therapy of osteoarthritis.

Zi-Jian Zhang, Ying-Ke Hou, Ming-Wa Chen, Xue-Zhao Yu, Si-Yu Chen, Ya-Ru Yue, Xiong-Tian Guo, Jin-Xiang Chen, Quan Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zi-Jian Zhang *Department of Medical Imaging, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
Ying-Ke Hou *Department of Medical Imaging, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
Ming-Wa ChenNMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Xue-Zhao YuDepartment of Medical Imaging, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
Si-Yu ChenDepartment of Medical Imaging, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
Ya-Ru YueDepartment of Medical Imaging, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
Xiong-Tian GuoDepartment of Medical Imaging, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
Jin-Xiang ChenNMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China. jxchen@smu.edu.cn.
Quan ZhouDepartment of Medical Imaging, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China. zhouquan3777@smu.edu.cn.
Third Affiliated Hospital of Southern Medical University · CNGuangdong Pharmaceutical University · CNSouthern Medical University · CN

Funding

National Natural Science Foundation of China 81630046
6 · The paper itself

Abstract

The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the mechanism. The inadequate response to monotherapy methods, suboptimal efficacy caused by undesirable bioavailability, short retention, and lack of stimulus-responsiveness, are few unresolved issues. Herein, we report a pH-responsive metal-organic framework (MOF), namely, MIL-101-NH

Indexed as

CurcuminMetal-Organic FrameworksOsteoarthritisBasic Helix-Loop-Helix ProteinsChondrocytesHumansHydrogen-Ion ConcentrationInflammationRNA, Small InterferingBasic Helix-Loop-Helix ProteinsCurcuminMetal-Organic FrameworksMIL-101RNA, Small InterferingCurcuminGene therapyMetal-organic frameworksOsteoarthritis therapypH-Responsive materials

Identifiers

PMID36650517
PMCPMC9847079
OpenAlexW4317034465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.