ArticlePediatric research2023
Linking specific biological signatures to different childhood adversities: findings from the HERO project.
Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06669624 (Leveraging Scientific Advances to Strengthen the Implementation, Evaluation, and Impacts of Intervention Programs for Children Experiencing Early Life Adversity), which is not on this map. Cited by 9 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leveraging Scientific Advances to Strengthen the Implementation, Evaluation, and Impacts of Intervention Programs for Children Experiencing Early Life Adversity
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adrenarche, social cognition, and the development and evolution of autism spectrum traits.Frontiers in psychiatry · 2025Pooled it
- Adverse childhood events and mental health problems in cancer survivors: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Adrenarche as a regulator of sensitivity to early adversity.Journal of neuroendocrinology · 2026Review
- Unpredictability is a childhood adversity that contributes to mental health problems.Nature. Mental health · 2026Article
- Methodological Considerations in Saliva-Based Biomarker Research: Addressing Patient-Specific Variability in Translational Research Protocols.Current protocols · 2025Article
- The impact of early childhood adversity on adult cognitive performance: The mediating roles of childhood cognitive ability and educational attainment.Social science & medicine (1982) · 2025Article
- Child Opportunity Index at birth and asthma with recurrent exacerbations in the US ECHO program.The Journal of allergy and clinical immunology · 2025Article
- Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundAlthough investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited.
methodsAssociations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol, cortisone, and dehydroepiandrosterone) were examined in two samples of young U.S. children (N = 142; N = 145).
resultsChildren exposed to higher SES-D had higher levels of TNF-α (B = 0.13, p = 0.011), IL-1β (B = 0.10, p = 0.033), and DHEA (B = 0.16, p = 0.011). Higher family dysfunction was associated with higher cortisol (B = 0.08, p = 0.033) and cortisone (B = 0.05, p = 0.003). An interaction between SES-D and family dysfunction was observed for cortisol levels (p = 0.020) whereby children exposed to lower/average levels of SES-D exhibited a positive association between family dysfunction and cortisol levels, whereas children exposed to high levels of SES-D did not. These findings were partially replicated in the second sample.
conclusionsOur results indicate that these biological response systems may react differently to different forms of early-life adversity. IMPACT: Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking. Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA. Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage. Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities.
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