Evidence map›Paper›PMID 36650272›Full record

ArticleLeukemia2023

Age-related decline in LEPR

Thao Trinh, James Ropa, Scott Cooper, Arafat Aljoufi, Anthony Sinn, Maegan Capitano, Hal E Broxmeyer, Mark H Kaplan

Abstract readLetter
In one paragraph

Article in Leukemia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Aging and immunity: the age-old tango.Genes & development · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thao Trinh *Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. thtrinh@iupui.edu.
James Ropa *Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Scott CooperDepartment of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Arafat AljoufiDepartment of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Anthony SinnIn Vivo Therapeutics Core, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Maegan CapitanoDepartment of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Hal E BroxmeyerDepartment of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Mark H KaplanDepartment of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mkaplan2@iu.edu.ORCID 0000-0002-2923-8245

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2017 to 2026
$24.9M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
REGULATION OF HEMATOPOIETIC CELL PRODUCTIONT32DK007519 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1986 to 2020
$7.1M
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
Indiana Medical Scientist/Engineer Training ProgramT32GM148382 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Benjamin Gaston, Emily K Sims · 2023 to 2026
$3.9M
Controlling Influences of Oxygen Tension and CD26/DPP4 Enzymatic Activity on Regulation of Hematopoietic Stem/Progenitor Cells and Hematopoiesis During Health, Ageing, and DiseaseR35HL139599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E. · 2018 to 2021
$3.1M
Proteotranscriptomic regulation of homing and engraftment in hematopoietic stem and progenitor cells for hematopoietic cell transplantationF32HL160072 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ROPA, JAMES PATRICK · 2021 to 2022
$80k
NCI NIH HHS P30 CA082709NHLBI NIH HHS F32 HL160072NHLBI NIH HHS R35 HL139599NIDDK NIH HHS T32 DK007519NIDDK NIH HHS U54 DK106846NIGMS NIH HHS P20 GM121176NIGMS NIH HHS T32 GM077229NIGMS NIH HHS T32 GM148382
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hematopoietic Stem CellsAgingHumansReceptors, LeptinLEPR protein, humanReceptors, Leptin

Identifiers

PMID36650272
PMCPMC9991916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.