Evidence map›Paper›PMID 36650173›Full record

ArticleNature communications2023

BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases.

Saaket Agrawal, Marcus D R Klarqvist, Nathaniel Diamant, Takara L Stanley, Patrick T Ellinor, Nehal N Mehta, Anthony Philippakis, Kenney Ng, Melina Claussnitzer, Steven K Grinspoon and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saaket Agrawal *Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-2535-4759
Marcus D R Klarqvist *Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7630-2708
Nathaniel DiamantData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1738-304X
Takara L StanleyMetabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Patrick T EllinorCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Anthony PhilippakisData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6953-3794
Kenney NgCenter for Computational Health, IBM Research, Cambridge, MA, USA.
Melina ClaussnitzerCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Steven K GrinspoonMetabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Puneet BatraData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6822-0593
Amit V KheraCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. avkhera@mgh.harvard.edu.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 1985 to 2008
$37.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Enabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5M
Physiologic Growth Hormone Effects in HIV LipodystrophyR01DK063639 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GRINSPOON, STEVEN K. · 2003 to 2012
$4.3M
Polygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1M
Medical Research Council MC_PC_17228NCRR NIH HHS M01 RR001066NCRR NIH HHS UL1 RR025758NHGRI NIH HHS K08 HG010155NHGRI NIH HHS U01 HG011719NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK063639
6 · The paper itself

Abstract

For any given body mass index (BMI), individuals vary substantially in fat distribution, and this variation may have important implications for cardiometabolic risk. Here, we study disease associations with BMI-independent variation in visceral (VAT), abdominal subcutaneous (ASAT), and gluteofemoral (GFAT) fat depots in 40,032 individuals of the UK Biobank with body MRI. We apply deep learning models based on two-dimensional body MRI projections to enable near-perfect estimation of fat depot volumes (R

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Adipose TissueAdiposityBody Mass IndexHumansIntra-Abdominal FatRisk Factors

Identifiers

PMID36650173
PMCPMC9844175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.