Evidence map›Paper›PMID 36650144›Full record

ArticleNature communications2023

Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping.

Maksim Kitsak, Alexander Ganin, Ahmed Elmokashfi, Hongzhu Cui, Daniel A Eisenberg, David L Alderson, Dmitry Korkin, Igor Linkov

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maksim KitsakFaculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, 2600 GA, Delft, The Netherlands. maksim.kitsak@gmail.com.ORCID 0000-0002-6862-6021
Alexander GaninUniversity of Virginia, Department of Systems and Information Engineering, Charlottesville, VA, 22904, USA.ORCID 0000-0003-2193-0373
Ahmed ElmokashfiSimula Metropolitan Center for Digital Engineering, Oslo, Norway.ORCID 0000-0001-9964-214X
Hongzhu CuiBioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA, 01609, USA.
Daniel A EisenbergDepartment of Operations Research, Naval Postgraduate School, Monterey, CA, 93943, USA.
David L AldersonDepartment of Operations Research, Naval Postgraduate School, Monterey, CA, 93943, USA.
Dmitry KorkinBioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA, 01609, USA.ORCID 0000-0002-3875-9085
Igor LinkovU.S. Army Engineer Research and Development Center, Environmental Laboratory, Concord, MA, 01742, USA. igor.linkov@usace.mil.ORCID 0000-0002-0823-8107

Funding

Predicting the functional impact of alternative splicing on protein-protein interactions using an integrated approachR01LM014017 · NLM · WORCESTER POLYTECHNIC INSTITUTE · PI KORKIN, DMITRY, SHEYNKMAN, GLORIA · 2022 to 2025
$1.3M
NLM NIH HHS R01 LM014017
6 · The paper itself

Abstract

Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Computing shortest paths is a straightforward task when the network of interest is fully known, and there are a plethora of computational algorithms for this purpose. Unfortunately, our maps of most large networks are substantially incomplete due to either the highly dynamic nature of networks, or high cost of network measurements, or both, rendering traditional path finding methods inefficient. We find that shortest paths in large real networks, such as the network of protein-protein interactions and the Internet at the autonomous system level, are not random but are organized according to latent-geometric rules. If nodes of these networks are mapped to points in latent hyperbolic spaces, shortest paths in them align along geodesic curves connecting endpoint nodes. We find that this alignment is sufficiently strong to allow for the identification of shortest path nodes even in the case of substantially incomplete networks, where numbers of missing links exceed those of observable links. We demonstrate the utility of latent-geometric path finding in problems of cellular pathway reconstruction and communication security.

Indexed as

AlgorithmsSignal TransductionCell CommunicationCommunication

Identifiers

PMID36650144
PMCPMC9845360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.