Evidence map›Paper›PMID 36650072›Full record

ArticleActa physiologica (Oxford, England)2023

Rats lacking Ucp1 present a novel translational tool for the investigation of thermogenic adaptation during cold challenge.

Jaycob D Warfel, Carrie M Elks, David S Bayless, Bolormaa Vandanmagsar, Allison C Stone, Samuel E Velasquez, Paola Olivares-Nazar, Robert C Noland, Sujoy Ghosh, Jingying Zhang and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Jaycob D WarfelPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID 0000-0001-7501-0631
Carrie M ElksPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
David S BaylessPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Bolormaa VandanmagsarPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Allison C StonePennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Samuel E VelasquezPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Paola Olivares-NazarPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Robert C NolandPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Sujoy GhoshPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Jingying ZhangPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Randall L MynattPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Pennington Biomedical Research Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JUDD E SHELLITO · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN · 2005 to 2026
$26.5M
Mentoring Obesity and Diabetes Research in LouisianaP20GM103528 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2012 to 2015
$8.8M
Training in Botanical Approaches to Combat Metabolic SyndromeT32AT004094 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BRANTLEY, PHILLIP J, STEPHENS, JACQUELINE M · 2009 to 2024
$5.7M
Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
Defining the role of skeletal muscle peroxisomes in glucose homeostasisR01DK103860 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI NOLAND, ROBERT CHARLES · 2015 to 2019
$1.7M
Molecular Genetics of ThermogenesisR01DK089641 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MYNATT, RANDALL LEE, YOUNG, MARTIN E · 2010 to 2013
$1.6M
HuR as a Regulator of Skeletal Muscle MetabolismK01DK116914 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI WARFEL, JAYCOB DALTON · 2019 to 2022
$452k
Oncostatin M as a mediator of adipose tissue immune balanceR03DK122121 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ELKS, CARRIE M · 2020 to 2021
$222k
NCCIH NIH HHS T32 AT004094NCCIH NIH HHS T32-AT-004094NIDDK NIH HHS K01-DK-116194NIDDK NIH HHS K01 DK116914NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK089641NIDDK NIH HHS R01-DK-089641NIDDK NIH HHS R01 DK103860NIDDK NIH HHS R03 DK122121NIDDK NIH HHS T32-DK-6458413NIGMS NIH HHS P20 GM103528NIGMS NIH HHS U54 GM104940NIH HHS R01DK103860
6 · The paper itself

Abstract

aimValuable studies have tested the role of UCP1 on body temperature maintenance in mice, and we sought to knockout Ucp1 in rats (Ucp1

methodsWe used CRISPR/Cas9 technology to create Ucp1

resultsUcp1

conclusionRoom temperature presented sufficient cold stress to rats lacking UCP1 to activate compensatory thermogenic mechanisms in skeletal muscle, which were only activated in control rats following exposure to 4°C. These results provide novel insight into thermogenic responses to UCP1 deficiency; and highlight Ucp1

Indexed as

Adipose Tissue, BrownCold TemperatureAdipose Tissue, WhiteAnimalsBody WeightMammalsMitochondrial ProteinsRatsThermogenesisUncoupling Protein 1Mitochondrial ProteinsUcp1 protein, mouseUcp1 protein, ratUncoupling Protein 1brown adipose tissuenon-shiveringthermogenesisUCP1

Identifiers

PMID36650072
PMCPMC11318575
OpenAlexW4317360131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.