Evidence map›Paper›PMID 36649932›Full record

ArticleNeuropsychopharmacology reports2023

Bidirectional effects of voluntary exercise on the expression of Bdnf isoforms in the hippocampus of Hatano rat strains displaying different activity levels.

Shuichi Chiba, Hikaru Asano, Shogo Moriya, Taichi Hatakeyama, Shohei Kobayashi, Ryo Ohta, Maiko Kawaguchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Modulation of toxicity effects of CuSOScientific reports · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Shuichi ChibaLaboratory of Physiology, Faculty of Veterinary Medicine, Okayama University of Science, Imabari City, Japan.ORCID 0000-0001-7480-4827
Hikaru AsanoLaboratory of Animal Behavior and Environmental Science, School of Agriculture, Meiji University, Kawasaki, Japan.
Shogo MoriyaDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-7702-9520
Taichi HatakeyamaLaboratory of Animal Behavior and Environmental Science, School of Agriculture, Meiji University, Kawasaki, Japan.
Shohei KobayashiLaboratory of Animal Behavior and Environmental Science, School of Agriculture, Meiji University, Kawasaki, Japan.ORCID 0000-0001-5859-2027
Ryo OhtaHatano Research Institute, Food and Drug Safety Center, Hadano, Japan.ORCID 0000-0002-8362-7081
Maiko KawaguchiLaboratory of Animal Behavior and Environmental Science, School of Agriculture, Meiji University, Kawasaki, Japan.ORCID 0000-0002-3184-9483
Meiji University · JPChiba University · JPFood and Drug Safety Center · JPOkayama University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-derived neurotrophic factor has functional mRNA isoforms, whose expression is assumed to mediate the beneficial effects of exercise in neuropsychiatric disorders. This study aims to reveal the mechanism of intensity-dependent effects of voluntary exercise, focusing on the expression of Bdnf mRNA isoforms in Hatano rats. Animals with different voluntary activity were housed in cages with a locked or unlocked wheel for 5 weeks. The expression levels of Bdnf isoforms and the corresponding coding sequences (CDS) were measured in the hippocampus using real-time polymerase chain reaction (PCR). We found that exercise increased the expression of Bdnf isoform containing exon 1 in the high-intensity-running strain and decreased the expressions of Bdnf exon 1, 3, 6, 7, 8, and 9a in mild-intensity-running animal. The expression of Bdnf CDS was increased by exercise in both strains. These results suggest that expressions of Bdnf isoforms depend on the intensities of voluntary exercise, but the involvement of subjects' genetic background could not be excluded. Our finding also implies that the bidirectional effects of exercise may not be mediated via the final product of Bdnf.

Indexed as

Physical Conditioning, AnimalRNA IsoformsAnimalsBrain-Derived Neurotrophic FactorHippocampusProtein IsoformsRatsBdnf protein, ratBrain-Derived Neurotrophic FactorProtein IsoformsRNA Isoformsbrain-derived neurotrophic factorexerciseHatano rats

Identifiers

PMID36649932
PMCPMC10009423
OpenAlexW4317358816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.