Evidence map›Paper›PMID 36649474›Full record

ArticleACS applied materials & interfaces2023

Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules.

Kern Hast, M Rhia L Stone, Zhaojun Jia, Melih Baci, Tushar Aggarwal, Enver Cagri Izgu

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Polymeric Nanomaterials for Atherosclerosis Diagnosis and Treatment.Polymer science & technology (Washington, D.C.) · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kern HastDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey 08854, United States.
M Rhia L StoneDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey 08854, United States.
Zhaojun JiaDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey 08854, United States.
Melih BaciDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey 08854, United States.
Tushar AggarwalDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey 08854, United States.ORCID 0000-0002-6641-0964
Enver Cagri IzguDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey 08854, United States.ORCID 0000-0001-6673-3635

Funding

Rutgers Optimizes Innovation (ROI) ProgramU01HL150852 · NHLBI · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI LIBUTTI, STEVEN K., PANETTIERI, REYNOLD ALEXANDER · 2019 to 2022
$4.4M
Activity-Based Aptamers as Bioimaging Tools for Probing Organics, Inorganics, and EnzymesR21EB029548 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI IZGU, ENVER C · 2020 to 2021
$615k
NHLBI NIH HHS U01 HL150852NIBIB NIH HHS R21 EB029548
6 · The paper itself

Abstract

The functionalization of material surfaces with biologically active molecules is crucial for enabling technologies in life sciences, biotechnology, and medicine. However, achieving biocompatibility and bioorthogonality with current synthetic methods remains a challenge. We report herein a novel surface functionalization method that proceeds chemoselectively and without a free transition metal catalyst. In this method, a coating is first formed via the tyrosinase-catalyzed putative polymerization of a tetrazine-containing catecholamine (DOPA-Tet). One or more types of molecule of interest containing

Indexed as

Staphylococcus aureusVancomycinAnimalsBiofilmsDihydroxyphenylalanineMammalsPeptides, CyclicDihydroxyphenylalaninePeptides, CyclicVancomycinbioorthogonalcatecholenzymefibroblastStaphylococcus aureustetrazine ligationtyrosinase

Identifiers

PMID36649474
PMCPMC10069157

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.