Evidence map›Paper›PMID 36649445›Full record

ArticleCirculation. Cardiovascular imaging2023

Nuclear Methods for Immune Cell Imaging: Bridging Molecular Imaging and Individualized Medicine.

Gyu Seong Heo, Johanna Diekmann, James T Thackeray, Yongjian Liu

Abstract read
In one paragraph

Article in Circulation. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Longitudinal [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gyu Seong Heo *Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO (G.S.H., Y. L.).ORCID 0000-0001-6200-4742
Johanna Diekmann *Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany (J.D., J.T.T.).
James T ThackerayDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany (J.D., J.T.T.).ORCID 0000-0002-9031-100X
Yongjian LiuMallinckrodt Institute of Radiology, Washington University, St. Louis, MO (G.S.H., Y. L.).ORCID 0000-0002-1118-1535

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
Molecular Imaging CCR2 Lung Inflammation and FibrosisR01HL151685 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2021 to 2025
$3.7M
PET Detection of CCR2 in Human AtherosclerosisR01HL150891 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., WOODARD, PAMELA K · 2020 to 2024
$3.7M
CCR2 Targeted Molecular Imaging and Treatment of Abdominal Aortic AneurysmsR01HL153436 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., ZAYED, MOHAMED A. · 2020 to 2023
$3.0M
PET IMAGING CCR2 IN LUNG INFLAMMATIONR01HL131908 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN, LIU, YONGJIAN · 2016 to 2018
$2.0M
NHLBI NIH HHS R01 HL131908NHLBI NIH HHS R01 HL150891NHLBI NIH HHS R01 HL151685NHLBI NIH HHS R01 HL153436NHLBI NIH HHS R35 HL145212NIBIB NIH HHS P41 EB025815
6 · The paper itself

Abstract

Inflammation is a key mechanistic contributor to the progression of cardiovascular disease, from atherosclerosis through ischemic injury and overt heart failure. Recent evidence has identified specific roles of immune cell subpopulations in cardiac pathogenesis that diverges between individual patients. Nuclear imaging approaches facilitate noninvasive and serial quantification of inflammation severity, offering the opportunity to predict eventual outcome, stratify patient risk, and guide novel targeted molecular therapies against specific leukocyte subpopulations. Here, we will discuss the established and emerging nuclear imaging methods to label and track exogenous and endogenous immune cells, with a particular focus on clinical situations in which targeted molecular inflammation imaging would be advantageous. The expanding options for imaging inflammation provide the foundation to bridge between molecular imaging and individual therapy.

Indexed as

Cardiovascular DiseasesPositron-Emission TomographyHumansInflammationMolecular ImagingPrecision Medicineheart failureinflammationmagnetic resonance imagingmyocardial infarctionpositron emission tomography

Identifiers

PMID36649445
PMCPMC9858352

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.