Evidence map›Paper›PMID 36649429›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Synthetic peptides that form nanostructured micelles have potent antibiotic and antibiofilm activity against polymicrobial infections.

Shuli Chou, Huating Guo, Franz G Zingl, Shiqing Zhang, Jonida Toska, Bocheng Xu, Yili Chen, Peisong Chen, Matthew K Waldor, Wenjing Zhao and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Shuli ChouShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong 518107, China.
Huating GuoShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong 518107, China.
Franz G ZinglDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115.
Shiqing ZhangShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong 518107, China.
Jonida ToskaDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-6115-8862
Bocheng XuCollege of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Yili ChenDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Peisong ChenDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Matthew K WaldorDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0003-1843-7000
Wenjing ZhaoShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong 518107, China.
John J MekalanosDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.
Xiangyu MouShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong 518107, China.
Brigham and Women's Hospital · USHarvard University · USSun Yat-sen University · CNZhejiang University · CN

Funding

Genetic analysis of toxinogenesis of Vibrio choleraeR37AI018045 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI John Joseph Mekalanos · 1989 to 2026
$12.8M
Genetic Analysis of Toxinogenesis in Vibrio CholeraeR01AI018045 · NIAID · HARVARD MEDICAL SCHOOL · PI MEKALANOS, JOHN JOSEPH · 2009 to 2018
$6.7M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI018045NIAID NIH HHS R37 AI018045
6 · The paper itself

Abstract

The emergence of multidrug-resistant bacterial pathogens is a growing threat to global public health. Here, we report the development and characterization of a panel of nine-amino acid residue synthetic peptides that display potent antibacterial activity and the ability to disrupt preestablished microbial biofilms. The lead peptide (Peptide K6) showed bactericidal activity against

Indexed as

Anti-Bacterial AgentsCoinfectionAnimalsAntimicrobial Cationic PeptidesBiofilmsMiceMicellesMicrobial Sensitivity TestsPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsAntimicrobial Cationic PeptidesMicellesantimicrobial peptidesnanostructuresoligopeptide antibiotics

Identifiers

PMID36649429
PMCPMC9942841
OpenAlexW4317033249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.