ArticlePLoS biology2023
Cell wall dynamics stabilize tip growth in a filamentous fungus.
Article in PLoS biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Article
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- A Chickpea NCR Peptide Suppresses Postharvest Alternaria alternata Infection by Disrupting Fungal Membranes, Mitochondria and Respiration.Molecular plant pathology · 2026Article
- Snooping helices: The elastic path finding algorithm of growing hyphae.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in anJournal of the American Chemical Society · 2026Article
- Reframing the substrate as an active process component in fungal solid-state fermentation of foods.NPJ science of food · 2026Review
- Algal extract as a key protective agent: Jania rubens-enriched PVA/CMC coatings for postharvest onion disease control.BMC plant biology · 2026Article
- A surface morphology-based inference method for the cell wall elasticity profile in tip-growing cells.PLoS computational biology · 2026Article
- Greening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy.International journal of nanomedicine · 2026Review
- Regulation of extracellular vesicles for protein secretion inMicrobial cell (Graz, Austria) · 2026Article
- Revisiting fungal polarized growth: from Spitzenkörper to crescent accumulation of secretory vesicles.iScience · 2025Article
- Revealing structure and shaping priorities in plant and fungal cell wall architecture via solid-state NMR.Cell surface (Amsterdam, Netherlands) · 2025Review
- Climate-linked biogeography of mycorrhizal fungal spore traits.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cell walls of filamentous fungi - challenges and opportunities for biotechnology.Applied microbiology and biotechnology · 2025Review
- Bioinspired Strong and Tough Layered Bulk Composites via Mycelial Interface Anchoring Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The curtain model as an alternative and complementary to the classic turgor concept of filamentous fungi.Archives of microbiology · 2025Review
- Analysis of Cell Wall Mechanics in Fission Yeast.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Mechanical strategies supporting growth and size diversity in Filamentous Fungi.Molecular biology of the cell · 2024Article
- Chitinase GeneInternational journal of molecular sciences · 2024Article
- Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β-1,3-glucan synthesis inhibition.Nature communications · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyphal tip growth allows filamentous fungi to colonize space, reproduce, or infect. It features remarkable morphogenetic plasticity including unusually fast elongation rates, tip turning, branching, or bulging. These shape changes are all driven from the expansion of a protective cell wall (CW) secreted from apical pools of exocytic vesicles. How CW secretion, remodeling, and deformation are modulated in concert to support rapid tip growth and morphogenesis while ensuring surface integrity remains poorly understood. We implemented subresolution imaging to map the dynamics of CW thickness and secretory vesicles in Aspergillus nidulans. We found that tip growth is associated with balanced rates of CW secretion and expansion, which limit temporal fluctuations in CW thickness, elongation speed, and vesicle amount, to less than 10% to 20%. Affecting this balance through modulations of growth or trafficking yield to near-immediate changes in CW thickness, mechanics, and shape. We developed a model with mechanical feedback that accounts for steady states of hyphal growth as well as rapid adaptation of CW mechanics and vesicle recruitment to different perturbations. These data provide unprecedented details on how CW dynamics emerges from material secretion and expansion, to stabilize fungal tip growth as well as promote its morphogenetic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.