ArticleHuman brain mapping2023
Whole-brain functional gradients reveal cortical and subcortical alterations in patients with episodic migraine.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates.Frontiers in neurology · 2026Pooled it
- Acupuncture for Migraine Without Aura and Connection-Based Efficacy Prediction: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Integrated anatomical and functional connectivity mapping in episodic migraine: a spectral graph theory approach.Scientific reports · 2026Article
- Topological signatures differentiating episodic and chronic phenotypes in migraine without aura: a multi-scale analysis revealing divergent network profiles.The journal of headache and pain · 2026Article
- Multimodal MRI of episodic cluster headache reveals frontal cortical alterations and network-level connectivity changes.The journal of headache and pain · 2026Article
- 5.0 T MRI reveals characteristic alterations in visual and somatomotor networks associated with migraine chronification: a single-center prospective cohort study.The journal of headache and pain · 2025Article
- The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache: A Narrative Review.Life (Basel, Switzerland) · 2025Review
- A robust multimodal brain MRI-based diagnostic model for migraine: validation across different migraine phases and longitudinal follow-up data.The journal of headache and pain · 2025Article
- The structure of spontaneous speech changes in Alzheimer's disease: Crosslingual evidence from English and Greek.PloS one · 2025Article
- Disruption of structural connectome hierarchy in age-related hearing loss.Frontiers in neuroscience · 2025Article
- Sex-specific topological structure associated with dementia via latent space estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study.The journal of headache and pain · 2024Article
- Migraine aura discrimination using machine learning: an fMRI study during ictal and interictal periods.Medical & biological engineering & computing · 2024Article
- Shifts in structural connectome organization in the limbic and sensory systems of patients with episodic migraine.The journal of headache and pain · 2024Article
- Functional gradients reveal cortical hierarchy changes in multiple sclerosis.Human brain mapping · 2024Article
- Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura.The journal of headache and pain · 2024Article
- Patients with episodic migraine without aura have an increased rate of delayed discounting.Brain and behavior · 2024Article
- Whole-brain functional gradients reveal cortical and subcortical alterations in patients with episodic migraine.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a type of headache with multiple neurological symptoms. Prior neuroimaging studies in patients with migraine based on functional magnetic resonance imaging have found regional as well as network-level alterations in brain function. Here, we expand on prior studies by establishing whole-brain functional connectivity patterns in patients with migraine using dimensionality reduction techniques. We studied functional brain connectivity in 50 patients with episodic migraine and sex- and age-matched healthy controls. Using dimensionality reduction techniques that project high-dimensional functional connectivity onto low-dimensional representations (i.e., eigenvectors), we found significant between-group differences in the eigenvectors between patients with migraine and healthy controls, particularly in the sensory/motor and limbic cortices. Furthermore, we assessed between-group differences in subcortical connectivity with subcortical weighted manifolds defined by subcortico-cortical connectivity multiplied by cortical eigenvectors and revealed significant alterations in the amygdala. Finally, leveraging supervised machine learning, we moderately predicted headache frequency using cortical and subcortical functional connectivity features, again indicating that sensory and limbic regions play a particularly important role in predicting migraine frequency. Our study confirmed that migraine is a hierarchical disease of the brain that shows alterations along the sensory-limbic axis, and therefore, the functional connectivity in these areas could be a useful marker to investigate migraine symptomatology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.