Evidence map›Paper›PMID 36649075›Full record

ArticleThe Journal of clinical investigation2023

A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome.

Christian Lacks Lino Cardenas, Lauren C Briere, David A Sweetser, Mark E Lindsay, Patricia L Musolino

Registry-linked trialAbstract read
In one paragraph

Article in The Journal of clinical investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02450851 (Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02450851 recruitingnot on this map

Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network

TypeobservationalSponsorNational Human Genome Research Institute (NHGRI)Ran2015 to 2028Enrolled20,000ConditionsGenetic Disease
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christian Lacks Lino CardenasCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lauren C BriereDivision of Genetics.
David A SweetserHarvard Medical School, Boston, Massachusetts, USA.
Mark E LindsayCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Patricia L MusolinoHarvard Medical School, Boston, Massachusetts, USA.

Funding

Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
Modeling and Therapeutic Approaches for Genetic VasculopathiesR01NS125353 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MARK E LINDSAY, Patricia L Musolino · 2022 to 2026
$3.5M
Effects of ABCD1 Deficiency on Endothelial Function and Permeability to Leukocytes in Cerebral X-linked AdrenoleukodystrophyR01NS117575 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MUSOLINO, PATRICIA L · 2020 to 2024
$2.0M
Novel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcificationK01HL164687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Christian Lacks Lino Cardenas · 2022 to 2026
$808k
NHGRI NIH HHS U01 HG007690NHLBI NIH HHS K01 HL164687NINDS NIH HHS R01 NS117575
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MicroRNAsCell ProliferationCells, CulturedMuscle, SmoothMyocytes, Smooth MuscleMicroRNAsCardiovascular diseaseStrokeVascular Biology

Identifiers

PMID36649075
PMCPMC9974090

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.