Evidence map›Paper›PMID 36648813›Full record

ArticleBiomimetics (Basel, Switzerland)2023

Towards a Novel Cost-Effective and Versatile Bioink for 3D-Bioprinting in Tissue Engineering.

Fabian Züger, Natascha Berner, Maurizio R Gullo

Open access · goldAbstract read
In one paragraph

Article in Biomimetics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Toward Origami-Inspired In Vitro Cardiac Tissue Models.ACS biomaterials science & engineering · 2025
    Article
  5. Scaffolds Bioink for Three-Dimensional (3D) Bioprinting.Food science of animal resources · 2025
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fabian ZügerInstitute for Medical Engineering and Medical Informatics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, CH-4312 Muttenz, Switzerland.ORCID 0000-0002-9254-8254
Natascha BernerInstitute for Medical Engineering and Medical Informatics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, CH-4312 Muttenz, Switzerland.
Maurizio R GulloInstitute for Medical Engineering and Medical Informatics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, CH-4312 Muttenz, Switzerland.ORCID 0000-0001-8236-0496
FHNW University of Applied Sciences and Arts · CHUniversity of Basel · CH

Funding

Swiss Nanoscience Institute (SNI) p1902
6 · The paper itself

Abstract

3D-bioprinting for tissue regeneration relies on, among other things, hydrogels with favorable rheological properties. These include shear thinning for cell-friendly extrusion, post-printing structural stability as well as physiologically relevant elastic moduli needed for optimal cell attachment, proliferation, differentiation and tissue maturation. This work introduces a cost-efficient gelatin-methylcellulose based hydrogel whose rheological properties can be independently optimized for optimal printability and tissue engineering. Hydrogel viscosities were designed to present three different temperature regimes: low viscosity for eased cell suspension and printing with minimal shear stress, form fidelity directly after printing and long term structural stability during incubation. Enzymatically crosslinked hydrogel scaffolds with stiffnesses ranging from 5 to 50 kPa were produced, enabling the hydrogel to biomimic cell environments for different types of tissues. The bioink showed high intrinsic cytocompatibility and tissues fabricated by embedding and bioprinting NIH 3T3 fibroblasts showed satisfactory viability. This novel hydrogel uses robust and inexpensive technology, which can be adjusted for implementation in tissue regeneration, e.g., in myocardial or neural tissue engineering.

Indexed as

3D-bioprintingbioinkcell-environment mimickingrheologyshear thinningtissue engineeringvariable stiffnessyield point

Identifiers

PMID36648813
PMCPMC9844313
OpenAlexW4313891696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.