Evidence map›Paper›PMID 36648734›Full record

ReviewJournal of the Association for Research in Otolaryngology : JARO2023

The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.

Jonathan F Ashmore, John S Oghalai, James B Dewey, Elizabeth S Olson, Clark E Strimbu, Yi Wang, Christopher A Shera, Alessandro Altoè, Carolina Abdala, Ana B Elgoyhen and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the Association for Research in Otolaryngology : JARO, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Swept Along: Measuring Otoacoustic Emissions Using Continuously Varying Stimuli.Journal of the Association for Research in Otolaryngology : JARO · 2024
    Review
  4. The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonathan F AshmoreUCL Ear Institute, University College London, London, UK.
John S OghalaiDepartment of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, USA.
James B DeweyDepartment of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, USA.
Elizabeth S OlsonDepartment of Otolaryngology Head and Neck Surgery, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA.
Clark E StrimbuDepartment of Otolaryngology Head and Neck Surgery, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA.
Yi WangDepartment of Otolaryngology Head and Neck Surgery, Vagelos College of Physicians and Surgeons, Columbia University, New York City, USA.
Christopher A SheraCaruso Department of Otolaryngology and Department of Physics and Astronomy, University of Southern California, Los Angeles, USA.
Alessandro AltoèCaruso Department of Otolaryngology and Department of Physics and Astronomy, University of Southern California, Los Angeles, USA.
Carolina AbdalaCaruso Department of Otolaryngology, University of Southern California, Los Angeles, USA.
Ana B ElgoyhenInstituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres" (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Ruth Anne EatockDepartment of Neurobiology, University of Chicago, Chicago, USA.
Robert M RaphaelDepartment of Bioengineering, Rice University, Houston, USA. rraphael@rice.edu.ORCID 0000-0003-4986-7847

Funding

THE CHOLINERGIC RESPONSE OF COCHLEAR HAIR CELLSR01DC001508 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Amanda M. Lauer · 1992 to 2026
$13.2M
UNDERSTANDING OTOACOUSTIC EMISSIONSR01DC003687 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher A Shera · 1999 to 2026
$9.8M
Cochlear mechanics in the mouseR01DC014450 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John S Oghalai · 2015 to 2026
$5.6M
Diversity Supplement to Auditory Mechanics and Cochlear AmplificationR01DC015362 · NIDCD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ELIZABETH S. OLSON · 2016 to 2026
$5.6M
Postnatal Cochlear Maturation and Sources of ImmaturityR01DC003552 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ABDALA, CAROLINA · 2003 to 2019
$5.5M
Synaptic Processing in the Vestibular SystemR01DC012347 · NIDCD · UNIVERSITY OF CHICAGO · PI EATOCK, RUTH ANNE, LYSAKOWSKI, ANNA · 2012 to 2022
$5.2M
Advanced Detection and Differential Diagnosis of Hearing Loss Using Otoacoustic EmissionsR01DC018307 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ABDALA, CAROLINA, SHERA, CHRISTOPHER A · 2020 to 2025
$2.8M
Role of tonic outer hair cell motility in cochlear amplificationR21DC019209 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DEWEY, JAMES BRADEN · 2020 to 2022
$495k
Influence of hair bundle properties on cochlear mechanicsF32DC016211 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DEWEY, JAMES BRADEN · 2017 to 2019
$179k
NIDCD NIH HHS F32 DC016211NIDCD NIH HHS R01 DC001508NIDCD NIH HHS R01 DC003552NIDCD NIH HHS R01 DC003687NIDCD NIH HHS R01 DC012347NIDCD NIH HHS R01 DC014450NIDCD NIH HHS R01 DC015362NIDCD NIH HHS R01 DC018307NIDCD NIH HHS R21 DC019209
6 · The paper itself

Abstract

In 1985, Bill Brownell and colleagues published the remarkable observation that cochlear outer hair cells (OHCs) express voltage-driven mechanical motion: electromotility. They proposed OHC electromotility as the mechanism for the elusive "cochlear amplifier" required to explain the sensitivity of mammalian hearing. The finding and hypothesis stimulated an explosion of experiments that have transformed our understanding of cochlear mechanics and physiology, the evolution of hair cell structure and function, and audiology. Here, we bring together examples of current research that illustrate the continuing impact of the discovery of OHC electromotility.

Indexed as

CochleaHair Cells, Auditory, OuterAnimalsHearingMammalsCochlear amplifierEfferentElectromotilityOptical coherence tomographyOtoacoustic emissionsPrestin

Identifiers

PMID36648734
PMCPMC10121982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.