Evidence map›Paper›PMID 36648526›Full record

ReviewApplied microbiology and biotechnology2023

Key insights into secondary metabolites from various Chaetomium species.

Vagish Dwibedi, Santosh Kumar Rath, Sahil Jain, Nayeli Martínez-Argueta, Ranjana Prakash, Sanjai Saxena, Leonardo Rios-Solis

Open access · bronzeAbstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  7. Antifungal activity of the culture filtrate ofFrontiers in microbiology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Effects of water-saving irrigation on microbial community structures, assembly, and metabolic activities in alfalfa rhizosphere soils.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  13. Article
  14. Biology and Application ofMicroorganisms · 2025
    Review
  15. Article
  16. Article
  17. Benefits ofMicroorganisms · 2024
    Article
  18. Article
  19. Abundance and diversity of fungal endophytes isolated from monk fruit (Plant-environment interactions (Hoboken, N.J.) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Vagish DwibediUniversity Institute of Biotechnology, Chandigarh University, Mohali, India.
Santosh Kumar RathSchool of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand-248009, India. skrath1985@gmail.com.ORCID http://orcid.org/0000-0001-8557-9450
Sahil JainDepartment of Biochemistry and Molecular Biology, Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Nayeli Martínez-ArguetaSchool of Natural and Environmental Sciences, Molecular Biology and Biotechnology Division , Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Ranjana PrakashDepartment of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala-147004, Punjab, India.
Sanjai SaxenaDepartment of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, 147004, Punjab, India.
Leonardo Rios-SolisSchool of Natural and Environmental Sciences, Molecular Biology and Biotechnology Division , Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK. leo.rios@ncl.ac.uk.
Newcastle University · GBThapar Institute of Engineering & Technology · INChandigarh University · INDehradun Institute of Technology University · INTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endophytic fungi have proved to be a major source of secondary metabolites, wherein the genus Chaetomium has emerged as a source of multifarious bioactive natural compounds belonging to diverse classes such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinone, chromones, depsidones, terpenoids, and steroids. The objective of this review is to encapsulate recent findings on various Chaetomium strains, such as C. globosum, C. cupreum, C. elatum, C. subspirale, C. olivaceum, C. indicum, and C. nigricolor known for production of beneficial secondary metabolites, with an insight into their origin and function. A thorough literature survey was conducted for obtaining Chaetomium-derived secondary metabolites, with a scope of future application into drug development efforts. More than 100 secondary metabolites, with various beneficial properties such as antitumor, cytotoxic, antimalarial, and enzyme inhibitory activities, were enlisted. We believe this review will enhance the understanding of beneficial effects conferred by various Chaetomium-derived secondary metabolites and emphasize their potential in serving novel drug development efforts. KEY POINTS: • Identified Chaetomium-derived metabolites with potential for drug development. • More than 100 beneficial metabolites are enlisted. • Benefits include anti-cancerous, antimalarial, and anti-enzymatic properties.

Indexed as

AntimalarialsAntineoplastic AgentsChaetomiumAntimalarialsAntineoplastic AgentsBioactivitiesChaetomiumDrug discoveryEndophytesNatural products

Identifiers

PMID36648526
PMCPMC9843691
OpenAlexW4316928811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.