Evidence map›Paper›PMID 36648432›Full record

ArticleeLife2023

GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar-pillar morphology.

Mark A Rutherford, Atri Bhattacharyya, Maolei Xiao, Hou-Ming Cai, Indra Pal, Maria Eulalia Rubio

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility.Autism research : official journal of the International Society for Autism Research · 2026
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  14. Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mark A RutherfordDepartment of Otolaryngology, Washington University School of Medicine, St Louis, United States.ORCID 0000-0002-2627-6254
Atri BhattacharyyaDepartment of Otolaryngology, Washington University School of Medicine, St Louis, United States.
Maolei XiaoDepartment of Otolaryngology, Washington University School of Medicine, St Louis, United States.
Hou-Ming CaiDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Indra PalDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Maria Eulalia RubioDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID 0000-0003-3536-6013
University of Pittsburgh · US

Funding

Mechanisms of hypersensitivity to sound-induced cochlear damageR01DC013048 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria-Eulalia Rubio-Valero · 2013 to 2026
$6.8M
EXCITATION AND EXCITOTOXICITY IN TYPE I COCHLEAR AFFERENTS: SYNAPTIC STRUCTURE AND FUNCTIONR01DC014712 · NIDCD · WASHINGTON UNIVERSITY · PI Mark Allen Rutherford · 2016 to 2026
$5.6M
Mechanisms of hypersensitivity to sound-induced cochlear damageR56DC013048 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUBIO-VALERO, MARIA-EULALIA · 2018 to 2018
$304k
NIDCD NIH HHS R01 DC013048NIDCD NIH HHS R01 DC014712NIDCD NIH HHS R56 DC013048NIH HHS DC013048NIH HHS DC14712
6 · The paper itself

Abstract

Cochlear sound encoding depends on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), but reliance on specific pore-forming subunits is unknown. With 5-week-old male C57BL/6J

Indexed as

CochleaSynapsesAnimalsMaleMiceMice, Inbred C57BLNeuronsReceptors, AMPAReceptors, GlutamateSynaptic VesiclesReceptors, AMPAReceptors, Glutamate3D reconstructionsconfocal imagingglutamate receptorsimmunolabelinginner hair cellsmouseneuroscienceqRT-PCR

Identifiers

PMID36648432
PMCPMC9891727
OpenAlexW4316928478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.