Evidence map›Paper›PMID 36648343›Full record

ReviewRadiology2023

An Integrated Radiologic-Pathologic Understanding of COVID-19 Pneumonia.

Jong Hyuk Lee, Jaemoon Koh, Yoon Kyung Jeon, Jin Mo Goo, Soon Ho Yoon

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Epidemiology of the COVID-19 pneumonia in a group of hospitals from Madrid-Spain during the full period of the State of Alarm HM cohort.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025
    Observational
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Multipotent mesenchymal stromal/stem cell-based therapies for acute respiratory distress syndrome: current progress, challenges, and future frontiers.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
  16. Review
  17. Article
  18. Quantitative Analysis for Lung Disease on Thin-Section CT.Diagnostics (Basel, Switzerland) · 2023
    Review
  19. Observational
  20. Ventilation Defects atRadiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jong Hyuk LeeFrom the Departments of Radiology (J.H.L., J.M.G., S.H.Y.) and Pathology (J.K., Y.K.J.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea (J.M.G.); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea (J.M.G.); and Cancer Research Institute, Seoul National University, Seoul, Korea (J.M.G.).ORCID 0000-0002-9594-683X
Jaemoon KohFrom the Departments of Radiology (J.H.L., J.M.G., S.H.Y.) and Pathology (J.K., Y.K.J.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea (J.M.G.); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea (J.M.G.); and Cancer Research Institute, Seoul National University, Seoul, Korea (J.M.G.).
Yoon Kyung JeonFrom the Departments of Radiology (J.H.L., J.M.G., S.H.Y.) and Pathology (J.K., Y.K.J.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea (J.M.G.); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea (J.M.G.); and Cancer Research Institute, Seoul National University, Seoul, Korea (J.M.G.).ORCID 0000-0001-8466-9681
Jin Mo GooFrom the Departments of Radiology (J.H.L., J.M.G., S.H.Y.) and Pathology (J.K., Y.K.J.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea (J.M.G.); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea (J.M.G.); and Cancer Research Institute, Seoul National University, Seoul, Korea (J.M.G.).ORCID 0000-0003-1791-7942
Soon Ho YoonFrom the Departments of Radiology (J.H.L., J.M.G., S.H.Y.) and Pathology (J.K., Y.K.J.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea (J.M.G.); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea (J.M.G.); and Cancer Research Institute, Seoul National University, Seoul, Korea (J.M.G.).ORCID 0000-0002-3700-0165
Seoul National University Hospital · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article reviews the radiologic and pathologic findings of the epithelial and endothelial injuries in COVID-19 pneumonia to help radiologists understand the fundamental nature of the disease. The radiologic and pathologic manifestations of COVID-19 pneumonia result from epithelial and endothelial injuries based on viral toxicity and immunopathologic effects. The pathologic features of mild and reversible COVID-19 pneumonia involve nonspecific pneumonia or an organizing pneumonia pattern, while the pathologic features of potentially fatal and irreversible COVID-19 pneumonia are characterized by diffuse alveolar damage followed by fibrosis or acute fibrinous organizing pneumonia. These pathologic responses of epithelial injuries observed in COVID-19 pneumonia are not specific to SARS-CoV-2 but rather constitute universal responses to viral pneumonia. Endothelial injury in COVID-19 pneumonia is a prominent feature compared with other types of viral pneumonia and encompasses various vascular abnormalities at different levels, including pulmonary thromboembolism, vascular engorgement, peripheral vascular reduction, a vascular tree-in-bud pattern, and lung perfusion abnormality. Chest CT with different imaging techniques (eg, CT quantification, dual-energy CT perfusion) can fully capture the various manifestations of epithelial and endothelial injuries. CT can thus aid in establishing prognosis and identifying patients at risk for deterioration.

Indexed as

COVID-19Lung DiseasesPneumoniaPneumonia, ViralHumansLungRadiologistsSARS-CoV-2

Identifiers

PMID36648343
PMCPMC9868683
OpenAlexW4316927933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.