ArticleBioinformatics (Oxford, England)2023
Protein-to-genome alignment with miniprot.
Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 319 papers.
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Who cites it
319 citing papers in PubMed.
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- Mutation accumulation in a hybrid parthenogenetic vertebrate.Molecular biology and evolution · 2026Article
- Genomic Insights Into the Body Size Evolution in Felidae (Mammalia: Carnivora).Ecology and evolution · 2026Article
- Evolution and domestication-trait associations of ultra-long centromere haplotypes in pepper plants.Nature ecology & evolution · 2026Article
- Chromosome-Level Genome Assembly ofPlants (Basel, Switzerland) · 2026Article
- From field to genome: non-lethal, on-site nanopore-only assembly of the endangered Grenada Frog (Pristimantis euphronides).BMC genomics · 2026Article
- Genus-Wide Pan-Genome Analysis ofPlants (Basel, Switzerland) · 2026Article
259 more citing papers are in PubMed but not listed here.
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Abstract
motivationProtein-to-genome alignment is critical to annotating genes in non-model organisms. While there are a few tools for this purpose, all of them were developed over 10 years ago and did not incorporate the latest advances in alignment algorithms. They are inefficient and could not keep up with the rapid production of new genomes and quickly growing protein databases.
resultsHere, we describe miniprot, a new aligner for mapping protein sequences to a complete genome. Miniprot integrates recent techniques such as k-mer sketch and vectorized dynamic programming. It is tens of times faster than existing tools while achieving comparable accuracy on real data. AVAILABILITY AND IMPLEMENTATION: https://github.com/lh3/miniport.
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