Evidence map›Paper›PMID 36648040›Full record

ArticleJACC. Cardiovascular imaging2023

3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy: Insights From the NHLBI International HCM Registry.

Bobak Heydari, Alessandro Satriano, Michael Jerosch-Herold, Paul Kolm, Dong-Yun Kim, Kathleen Cheng, Yuna L Choi, Panagiotis Antiochos, James A White, Masliza Mahmod and 16 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 12 institutions in 5 countries.

Bobak HeydariStephenson Cardiac Imaging Center, Department of Cardiac Sciences, University of Calgary, Calgary, Canada.
Alessandro SatrianoStephenson Cardiac Imaging Center, Department of Cardiac Sciences, University of Calgary, Calgary, Canada.
Michael Jerosch-HeroldDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Paul KolmMedStar Heart and Vascular Institute, Washington, DC, USA.
Dong-Yun KimNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Kathleen ChengCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Yuna L ChoiCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Panagiotis AntiochosDepartment of Cardiology, University of Lausanne, Switzerland.
James A WhiteStephenson Cardiac Imaging Center, Department of Cardiac Sciences, University of Calgary, Calgary, Canada.
Masliza MahmodDivision of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Kenneth ChanDivision of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Betty RamanDivision of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Milind Y DesaiCleveland Clinic, Cleveland, Ohio, USA.
Carolyn Y HoCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sarahfaye F DolmanMedStar Heart and Vascular Institute, Washington, DC, USA.
Patrice Desvigne-NickensNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Martin S MaronLahey Hospital & Medical Center, Boston, Massachusetts, USA.
Matthias G FriedrichMcGill University, Montreal, Canada.
Jeanette Schulz-MengerCharité Experimental Clinical Research Center and Helios Clinics Berlin-Buch, Berlin, Germany.
Stefan K PiechnikDivision of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Evan AppelbaumMen's Health, Boston, Massachusetts, USA.
William S WeintraubMedStar Heart and Vascular Institute, Washington, DC, USA.
Stefan NeubauerDivision of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Christopher M KramerCardiovascular Division, University of Virginia Health System, Charlottesville, Virginia, USA.
Raymond Y KwongCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: rykwong@bwh.harvard.edu.
HCMR Investigators
Brigham and Women's Hospital · USUniversity of Oxford · GBMedStar Heart & Vascular Institute · USUniversity of Calgary · CANational Heart Lung and Blood Institute · USCleveland Clinic · USHelios Hospital Berlin-Buch · DELahey Medical Center · USMcGill University · CAMen's Health Boston · USUniversity of Lausanne · CHUniversity of Virginia Health System · US

Funding

HCMR Novel Markers of Prognosis in Hypertrophic CardiomyopathyU01HL117006 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRAMER, CHRISTOPHER M., NEUBAUER, STEFAN · 2013 to 2017
$14.5M
British Heart Foundation PG/15/71/31731Department of HealthNHLBI NIH HHS U01 HL117006
6 · The paper itself

Abstract

backgroundAbnormal global longitudinal strain (GLS) has been independently associated with adverse cardiac outcomes in both obstructive and nonobstructive hypertrophic cardiomyopathy.

objectivesThe goal of this study was to understand predictors of abnormal GLS from baseline data from the National Heart, Lung, and Blood Institute (NHLBI) Hypertrophic Cardiomyopathy Registry (HCMR).

methodsThe study evaluated comprehensive 3-dimensional left ventricular myocardial strain from cine cardiac magnetic resonance in 2,311 patients from HCMR using in-house validated feature-tracking software. These data were correlated with other imaging markers, serum biomarkers, and demographic variables.

resultsAbnormal median GLS (> -11.0%) was associated with higher left ventricular (LV) mass index (93.8 ± 29.2 g/m

conclusionsAbnormal strain in hypertrophic cardiomyopathy is associated with other imaging and serum biomarkers of increased risk. Further follow-up of the HCMR cohort is needed to understand the independent relationship between LV strain and adverse cardiac outcomes in hypertrophic cardiomyopathy.

Indexed as

Cardiomyopathy, HypertrophicContrast MediaBiomarkersFemaleGadoliniumHumansMagnetic Resonance Imaging, CineNational Heart, Lung, and Blood Institute (U.S.)Predictive Value of TestsRegistriesStroke VolumeUnited StatesVentricular Function, LeftBiomarkersContrast MediaGadoliniumcardiac magnetic resonancehypertrophic cardiomyopathylate gadolinium enhancementleft ventricular hypertrophysarcomerestrain

Identifiers

PMID36648040
PMCPMC10802851
OpenAlexW4311441897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.