Evidence map›Paper›PMID 36647415›Full record

ReviewJournal of clinical and experimental hepatology

Current Status of Biomarkers and Molecular Diagnostic Tools for Rejection in Liver Transplantation: Light at the End of the Tunnel?

Ahmed El Sabagh, Islam B Mohamed, Fuad Z Aloor, Ahmed Abdelwahab, Manal M Hassan, Prasun K Jalal

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Diagnostic and predictive biomarkers of acute rejection after liver transplantation.International journal of surgery (London, England) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. The Science and Art of Immunosuppression in Liver Transplantation.Journal of clinical and experimental hepatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmed El SabaghDivision of Gastroenterology, Baylor College of Medicine, Houston, TX, USA.
Islam B MohamedDivision of Gastroenterology, Baylor College of Medicine, Houston, TX, USA.
Fuad Z AloorDivision of Gastroenterology, Baylor College of Medicine, Houston, TX, USA.
Ahmed AbdelwahabDivision of Gastroenterology, Baylor College of Medicine, Houston, TX, USA.
Manal M HassanDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Prasun K JalalDivision of Gastroenterology, Baylor College of Medicine, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strategies to minimize immune-suppressive medications after liver transplantation are limited by allograft rejection. Biopsy of liver is the current standard of care in diagnosing rejection. However, it adds to physical and economic burden to the patient and has diagnostic limitations. In this review, we aim to highlight the different biomarkers to predict and diagnose acute rejection. We also aim to explore recent advances in molecular diagnostics to improve the diagnostic yield of liver biopsies.

Indexed as

3BMBs, third bifurcation mucosal endo-bronchial biopsiesAMR, antibody mediated rejectionAPC, antigen presenting cellsAR, Acute rejectionATCMR, acute T-cell mediated rejectionATG, Anti-thymoglobulinAUC, area under curveAUROC, area under receiver operating characteristic curveB-HOT, Banff Human Organ TransplantbiomarkerCNI, Calcineurin inhibitorsdd cfDNA, donor-derived cell-free DNAdonor-derived cell-free DNADSA, Donor specific antibodiesFDA, Food and drug administrationFFPE, formalin fixed paraffin embedded preparationGLUT-4, glucose transport-4HLA, human leukocyte antigensHNMR, high nuclear magnetic resonanceILTS, International liver transplantation societyimmune-suppressionLiver transplantationLT, Liver transplantationMDWG, molecular diagnostic work groupMFI, mean fluorescence intensityMHC, major histo–compatibility complexmicro-RNAmiRNA, micro-RNAMMDXMMDX, Molecular microscopic diagnostic systemMMF, Mycophenolate Mofetilmolecular diagnosismRNA, messenger RNAMToR, Mechanistic target of Rapamycinnano-stringNPV, Negative predictive valuePPV, Positive predictive valueRATs, rejection associated transcriptsrejectionTBB, trans-bronchial biopsiesUNOS, United network for organ sharing and procurement

Identifiers

PMID36647415
PMCPMC9840072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.