ArticleScientific reports2016
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Harmonization of CSF and imaging biomarkers in Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification.Neurobiology of disease · 2024Pooled it
- A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains.Journal of Alzheimer's disease : JAD · 2017Pooled it
- Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition.Journal of advanced research · 2026Article
- Polymerase Chain Reaction Chips for Biomarker Discovery and Validation in Drug Development.Micromachines · 2025Review
- Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.Genome medicine · 2022Article
- Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders.Nature neuroscience · 2021Article
- Review
- Sortilin as a Biomarker for Cardiovascular Disease Revisited.Frontiers in cardiovascular medicine · 2021Article
- Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults.Genome medicine · 2020Article
- The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.Acta neuropathologica · 2020Article
- TheScience translational medicine · 2019Article
- Article
- Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.PLoS biology · 2018Article
- Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.Journal of Alzheimer's disease : JAD · 2018Article
- Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.Acta neuropathologica · 2017Article
Corrections and comments
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Authors and funding
26 authors at 20 institutions in 6 countries.
Funding
Abstract
Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested have been previously associated with various complex traits such as heart disease, inflammatory bowel disease, Type 2 diabetes and multiple sclerosis. These data suggest that these plasma protein levels may constitute informative endophenotypes for these complex traits. We found three potential pleiotropic genes: ABO for plasma SELE and ACE levels, FUT2 for CA19-9 and CEA plasma levels and APOE for ApoE and CRP levels. We also found multiple independent signals in loci associated with plasma levels of ApoH, CA19-9, FetuinA, IL6r and LPa. Our study highlights the power of biological traits for genetic studies to identify genetic variants influencing clinically relevant traits, potential pleiotropic effects and complex disease associations in the same locus.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.