Evidence map›Paper›PMID 36647265›Full record

ArticleOphthalmic epidemiology2023

Racial Differences in Retinopathy of Prematurity.

Jingyun Wang, Gui-Shuang Ying, Yinxi Yu, Lauren Tomlinson, Gil Binenbaum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Disparities in delivery hospital risk-adjusted outcomes for very low birthweight infants: the role of NICU volume and level of care.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Review
  4. Article
  5. The characteristics of racial disparity in retinopathy of prematurity outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Jingyun WangDepartment of Biological and Vision Science, State University of New York College of Optometry, New York, USA.
Gui-Shuang YingDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA.
Yinxi YuDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA.
Lauren TomlinsonDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, USA.
Gil BinenbaumDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USPenn Presbyterian Medical Center · USSUNY College of Optometry · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
Postnatal Growth and Retinopathy of Prematurity (G-ROP) StudiesR01EY021137 · NEI · CHILDREN'S HOSP OF PHILADELPHIA · PI BINENBAUM, GIL · 2012 to 2016
$4.3M
Secondary Analysis of Data from G-ROP StudyR21EY029776 · NEI · UNIVERSITY OF PENNSYLVANIA · PI YING, GUI-SHUANG · 2019 to 2020
$471k
Efficacy of Intermittent Occlusion in Amblyopia TreatmentR21EY026664 · NEI · SALUS UNIVERSITY · PI NEELY, DANIEL, WANG, JINGYUN · 2016 to 2017
$394k
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY021137NEI NIH HHS R21 EY026664NEI NIH HHS R21 EY029776
6 · The paper itself

Abstract

purposeTo delineate racial differences in the incidence and time course of ROP in a large cohort of premature infants.

methodsThe secondary analysis of data from the two Postnatal Growth and ROP Studies (G-ROP-1 and G-ROP-2) that were collected in 41 hospitals in North America from 2006 to 2017. According to self-reported maternal race, premature infants were classified into 3 groups: White (N = 5580), Black (N = 3252), and Asian (N = 353). Incidence, severity, and time course of ROP; plus disease; and postnatal weight gain rate were compared among racial groups.

resultsBlack infants had significantly smaller BW (mean 1035 vs. 1131 vs.1144 grams, P < .001) and lower GA (28.2 vs. 28.6, vs. 29.1 weeks, P < .001) than White and Asian infants. However, Black infants had lower incidences of severe ROP (11.1% vs. 12.4% vs. 11.9%), ROP (42.1% vs. 43.2% vs. 30.6%), and plus disease (3.6% vs. 6.3%, vs. 5.9%) than White and Asian infants (BW and GA adjusted risk ratio for Black vs. White 0.69 for severe ROP, 0.83 for ROP, 0.44 for plus disease, all P < .0001). Mean daily-weight-gain on days of life 11-20 and 21-30 were similar across groups (P > .05), but lower in Black and Asian infants on days 31-40 (P < .001). There were no differences in the timing of severe ROP and ROP across racial groups.

conclusionsDespite relatively lower GA, BW, and daily-weight-gain, Black preterm infants had lower incidences of ROP and plus disease than White preterm infants. The mechanisms for these differences require further investigation.

Indexed as

Infant, PrematureRetinopathy of PrematurityBirth WeightGestational AgeHumansIncidenceInfantInfant, NewbornRace FactorsRetrospective StudiesRisk Factorsinfantspremature infantsraceracial differenceretinaRetinopathy of prematurityweight gain

Identifiers

PMID36647265
PMCPMC10349899
OpenAlexW4316668633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.