ArticleBehavioral and brain functions : BBF2023
Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals.
Article in Behavioral and brain functions : BBF, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Investigation of the effects of two exercise protocols on behavioral and biochemical changes in ovariectomized rats exposed to single prolonged stress.IBRO neuroscience reports · 2026Article
- Voluntary versus forced exercise modulates anxiety‑like behaviors and hippocampal inflammation gene expression following traumatic stress in rats.IBRO neuroscience reports · 2026Article
- Chronic Chrysin, but Not Diazepam, Induces Anxiolytic-like Effects Without Behavioral Tolerance.Molecules (Basel, Switzerland) · 2026Article
- A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex.Learning & behavior · 2026Article
- Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review).International journal of molecular medicine · 2026Review
- Effects of Exercise Type and Sertraline on Anxiety and Social Behavior in a Female Rat Model of PTSD.Brain and behavior · 2026Article
- Pre-treatment with royal jelly, environmental enrichment, and their combination role in stress induced neurobehavioral deficits in male rats.IBRO neuroscience reports · 2026Article
- Estrous cycle stage gates the effect of stress on reward learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Sexually dimorphic effects of single prolonged stress on conditioned suppression behavior in Long Evans rats with no detection of altered mRNA expression of VGLUT1, GAD1, and Arc in the ventral hippocampus.Frontiers in behavioral neuroscience · 2026Article
- Sex-dependent effects of tamoxifen on mouse behavior.Behavioral and brain functions : BBF · 2025Article
- Low emotional contagious behavior induces PTSD susceptibility in observers and is related to the regulation of oxytocin receptor in mice.Cognitive, affective & behavioral neuroscience · 2025Article
- New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD).Neurochemical research · 2024Review
- Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model.Neuroscience bulletin · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Despite significant differences between men and women in the symptoms of PTSD and the response to therapeutic interventions, most PTSD studies have been done on male subjects. Continuing our previous study in male rats, this study aimed at better understanding the effect of a combination therapy of exercise with fluoxetine on female PTSD rats. The results were then compared with our past findings in male animals. Female adult Wistar rats subjected to PTSD were treated with moderate treadmill exercise or fluoxetine, or a combination of both. PTSD was induced by the single prolonged stress (SPS) model. Elevated plus-maze (EPM), serum and prefrontal BDNF, and fear extinctions were evaluated. The results showed that exercise plus fluoxetine decreased anxiety-like behavior, improved fear extinction, and increased BDNF changes in female rats. The effects of exercise alone were comparable with those of combination therapy except that combination therapy was more effective on OAT (open arm entry). The majority of results in female rats, except for those of prefrontal BDNF, 4th extinction, and OAT, were similar to those of male rats as shown in our previous study. According to our findings, exercise as a safe and cost-effective intervention can be considered as a complementary efficient option for PTSD treatment in both sexes. To achieve better treatment outcomes in PTSD patient, considering sex differences is recommended.
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