Evidence map›Paper›PMID 36646996›Full record

ArticleBMC geriatrics2023

Examining the association between neuropsychiatric symptoms among people with dementia and caregiver mental health: are caregiver burden and affiliate stigma mediators?

Yi-Jung Chen, Jian-An Su, Jung-Sheng Chen, Chieh-Hsiu Liu, Mark D Griffiths, Hsin-Chi Tsai, Chih-Cheng Chang, Chung-Ying Lin

Open access · goldAbstract read
In one paragraph

Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

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  9. Comparison of Views on Aging and Self-Perceptions of Aging Between Dementia Caregivers and Noncaregivers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
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  14. Suicide risks among caregivers of patients with depressive disorders.The Journal of international medical research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 2 countries.

Yi-Jung ChenInstitute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jian-An SuDepartment of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Jung-Sheng ChenDepartment of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.
Chieh-Hsiu LiuDepartment of Family Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
Mark D GriffithsInternational Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK.
Hsin-Chi TsaiDepartment of Psychiatry, School of Medicine, Tzu Chi University, Hualien, Taiwan. cssbmw45@gmail.com.
Chih-Cheng ChangDepartment of Psychiatry, Chi Mei Medical Center, Tainan, Taiwan. rabiata@gmail.com.
Chung-Ying LinInstitute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. cylin36933@gmail.com.
Chiayi Chang Gung Memorial Hospital · TWChi Mei Medical Center · TWE-Da Hospital · TWMinistry of Health and Welfare · TWNational Cheng Kung University · TWNational Cheng Kung University Hospital · TWNottingham Trent University · GBTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuropsychiatric disturbances are common manifestations of dementia disorders and are associated with caregiver burden and affiliate stigma. The present study investigated affiliate stigma and caregiver burden as mediators for the association between neuropsychiatric symptoms of people with dementia (PWD) and caregiver mental health such as depression and anxiety.

methodsA cross-sectional survey study was carried out with 261 dyads of PWD and informal caregivers from the outpatient department of a general hospital in Taiwan. The survey included the Caregiver Burden Inventory (CBI), the Affiliate Stigma Scale (ASS), the Taiwanese Depression Questionnaire (TPQ), and the Beck Anxiety Inventory (BAI). Mediation models were tested using the Hayes' PROCESS macro (Model 4 for parallel mediation model; Model 6 for sequentially mediation model).

resultsCaregiver burden, affiliate stigma, caregiver depression, and caregiver anxiety were significantly associated with neuropsychiatric symptoms. After controlling for several potentially confounding variables, it was found that PWD's neuropsychiatric symptoms, caregiver burden and affiliate stigma significantly explained 52.34% of the variance in caregiver depression and 37.72% of the variance in caregiver anxiety. The parallel mediation model indicated a significantly indirect path from PWD's neuropsychiatric symptoms to caregiver mental health through caregiver burden and affiliate stigma, while the direct effect was not significant. Moreover, there was a directional association between caregiver burden and affiliate stigma in the sequential mediation model.

conclusionsThese findings show that it is imperative to improve caregivers' perception of those with dementia to reduce internalized stigma and to improve caregivers' mental health. Implementation of affiliate stigma assessment in clinical practice would allow distinctions to be made between the impact of affiliate stigma and the consequences of caregiver burden to help inform appropriate intervention.

Indexed as

CaregiversDementiaCaregiver BurdenCross-Sectional StudiesHumansMental HealthAffiliate stigmaBurdenCaregiverDementiaMediation

Identifiers

PMID36646996
PMCPMC9841634
OpenAlexW4316372764

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.