Evidence map›Paper›PMID 36646994›Full record

Observational studyBMC cardiovascular disorders2023

Muscle strength trajectories and their association with postoperative health-related quality of life in patients undergoing coronary artery bypass grafting surgery: a prospective cohort study.

Johanneke Hartog, Sandra Dijkstra, Willem Dieperink, Trynke Hoekstra, Joke Fleer, Lucas H V van der Woude, Pim van der Harst, Maarten Nijsten, Massimo A Mariani, Fredrike Blokzijl

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03774342 (The Influence of Cognitive Decline on Quality of Life After Coronary Bypass), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03774342 unknown statusnot on this map

The Influence of Cognitive Decline on Quality of Life After Coronary Bypass

TypeobservationalSponsorUniversity Medical Center GroningenRan2018 to 2020Enrolled140ConditionsCoronary Artery Bypass, Cognitive DysfunctionArmsCoronary Artery Bypass Grafting
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Johanneke Hartog *Department of Cardiothoracic Surgery, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, AB41, 9713 GZ, Groningen, The Netherlands. j.hartog@umcg.nl.
Sandra Dijkstra *Department of Cardiothoracic Surgery, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, AB41, 9713 GZ, Groningen, The Netherlands.
Willem DieperinkDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Trynke HoekstraDepartment of Health Sciences and Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Joke FleerDepartment of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Lucas H V van der WoudeDepartment of Rehabilitation Medicine, Center for Human Movement Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Maarten NijstenDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Massimo A MarianiDepartment of Cardiothoracic Surgery, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, AB41, 9713 GZ, Groningen, The Netherlands.
Fredrike BlokzijlDepartment of Cardiothoracic Surgery, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, AB41, 9713 GZ, Groningen, The Netherlands.
University of Groningen · NLUniversity Medical Center Groningen · NLUniversity Medical Center Utrecht · NLVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with sarcopenia have a higher risk of poor recovery after coronary artery bypass grafting (CABG). Little is known about the impact of changes in muscle strength (the primary indicator for sarcopenia) on health-related quality of life (HR-QoL). This study aimed to (1) identify subgroups with different muscle strength trajectories, (2) identify differences in preoperative risk factors among trajectory group membership, and (3) explore their prognostic value on postoperative HR-QoL in patients undergoing CABG.

methodsIn this prospective observational study 131 patients undergoing elective CABG completed grip strength tests and HR-QoL questionnaires. Latent Class Growth Mixture Modelling (LCGMM) was used to identify clinically relevant trajectories (> 5% of study population) for weight-normalised grip strength, measured at admission, 3 days, and 6 months after surgery. Differences between trajectory group membership at baseline were evaluated. The impact of trajectory group membership on postoperative HR-QoL was evaluated with multiple linear regression models.

resultsDue to low numbers (n = 15), female patients were excluded from LCGMM and subsequent statistical analyses. In males (n = 116), we identified two main weight-normalised grip strength trajectories: a "stable average" trajectory with a slight decline immediately post-surgery and recovery to preoperative levels (n = 85) and a "high" trajectory with a considerable immediate decline after surgery but followed towards a higher level of recovery compared to preoperative level (n = 27). The "stable average" patients were older (68 vs. 57 years; P = 0.003), had more diabetes (27% vs. 4%; P = 0.01) and had a higher BMI (27.8 vs. 24.8; P = 0.005) compared to the "high" group. After correction for age, diabetes, and baseline HR-QoL, group trajectory membership was not associated with postoperative HR-QoL, yet an increase in individual change scores of weight-normalised grip strength was associated with a better postoperative HR-QoL. We also identified one small trajectory group (n = 4, ≤ 5%).

conclusionsThis study showed two relevant weight-normalised grip strength trajectories in male patients undergoing CABG, varying in important preoperative risk factors. While change scores of grip strength per weight did predict postoperative HR-QoL, the trajectory subgroups could not predict postoperative HR-QoL. Future research should focus on female patients, reacting potentially different on CABG and/or rehabilitation treatment. Trial registration NCT03774342, 12-12-2018.

Indexed as

Quality of LifeSarcopeniaCoronary Artery BypassFemaleHumansMaleMuscle StrengthProspective StudiesCardiac surgical proceduresHealth statusMuscle strengthMuscle weaknessMuscular atrophyQuality of lifeSarcopeniaSexTherapeutics

Identifiers

PMID36646994
PMCPMC9841699
OpenAlexW4316466576

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.