ArticleHead and neck pathology2023
A Low-grade Sinonasal Sarcoma Harboring EWSR1::BEND2: Expanding the Differential Diagnosis of Sinonasal Spindle Cell Neoplasms.
Article in Head and neck pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Molecular taxonomy of pancreatic neuroendocrine tumors reveals BEND2-fusions-driven transcriptional plasticity and therapeutic vulnerabilities.Cell reports. Medicine · 2026Article
- A pediatric low-grade sinonasal mesenchymal tumor harboring a novel CHD9::BEND2 fusion.Virchows Archiv : an international journal of pathology · 2025Article
- EWSR1::BEND2 fusion sarcoma of the urinary bladder - a case report and review of literature.Diagnostic pathology · 2025Review
- Recurrent BEND2 Fusion Genes Identified by Whole Transcriptome Sequencing of Nonfunctional Pancreatic Neuroendocrine Tumors Correlate With Poor Patient Prognosis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025Article
- Article
- EWSR1::BEND2 fusion sarcoma in bone: a report of two rare cases.Virchows Archiv : an international journal of pathology · 2025Article
- EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea.Head and neck pathology · 2025Article
- A primary intracranial neuroepithelial neoplasm with novel TCF3::BEND2 fusion: a case report.Acta neuropathologica communications · 2024Article
- Malignant Salivary Gland Neoplasm of the Tongue Base with EWSR1::BEND2 Fusion: An Unusual Case with Literature Review.Head and neck pathology · 2024Review
- Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion.Genes, chromosomes & cancer · 2024Article
- Identification of Novel/RareInternational journal of molecular sciences · 2024Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMolecular diagnostics has greatly refined sinonasal tumor pathology over the past decade. While much of the attention has focused on carcinomas, it is becoming clear that there are emerging mesenchymal neoplasms which have previously defied classification.
methodsHere, we present a 33-year-old woman with a multiply recurrent sinonasal spindle cell tumor exhibiting distinctive features, and not easily classifiable into a specific category.
resultsThe hypercellular tumor was composed of plump spindled cells, with uniform vesicular chromatin arranged as vague fascicles around a prominent hemangiopericytoma-like vasculature. The mitotic rate was brisk at 10 per 10 high power fields. By immunohistochemistry, it was only positive for EMA (focal) and SATB2 (diffuse, weak). Fusion analysis uncovered EWSR1::BEND2, a fusion which is best known for being seen in astroblastoma, but which has not yet been reported in sarcomas.
conclusionThis case underscores the utility of fusion analysis when confronted with a sinonasal spindle cell neoplasm which does not neatly fit into any specific category. It remains to be seen if EWSR1::BEND2 sinonasal sarcoma represents a distinct entity.
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